4UZH
SAR156497 an exquisitely selective inhibitor of Aurora kinases
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | AURORA 2 KINASE DOMAIN | polymer | 287 | 33342.2 | 1 | UniProt (O14965) Pfam (PF00069) | HOMO SAPIENS (HUMAN) | AURORA 2, AURORA/IPL1-RELATED KINASE 1, ARK-1, AURORA-RELATED KINASE 1, HARK1, BREAST TUMOR-AMPLIFIED KINASE, SERINE/THREONINE-PROTEIN KINASE 15, SERINE/THREONINE-PROTEIN KINASE 6, SERINE/THREONINE-PROTEIN KINASE AURORA-A, AURORA 2 KINASE DOMAIN |
| 2 | B (A) | (4S)-4-(2-fluorophenyl)-2,4,6,7,8,9-hexahydro-5H-pyrazolo[3,4-b][1,7]naphthyridin-5-one | non-polymer | 284.3 | 1 | Chemie (JVE) | |||
| 3 | C (A) | water | water | 18.0 | 152 | Chemie (HOH) |
Sequence modifications
A: 125 - 399 (UniProt: O14965)
| PDB | External Database | Details |
|---|---|---|
| Met 124 | - | expression tag |
| Ala 400 | - | expression tag |
| Ala 401 | - | expression tag |
| Ala 402 | - | expression tag |
| Leu 403 | - | expression tag |
| Glu 404 | - | expression tag |
| His 405 | - | expression tag |
| His 406 | - | expression tag |
| His 407 | - | expression tag |
| His 408 | - | expression tag |
| His 409 | - | expression tag |
| His 410 | - | expression tag |
| Asp 288 | Thr 288 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 33342.2 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 284.3 | |
| All* | Total formula weight | 33626.5 |
