4UZD

SAR156497 an exquisitely selective inhibitor of Aurora kinases

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	AURORA KINASE A	polymer	287	33328.2	2	UniProt (O14965) Pfam (PF00069)	HOMO SAPIENS (HUMAN)	AURORA 2, AURORA/IPL1-RELATED KINASE 1, ARK-1, AURORA-RELATED KINASE 1, HARK1, BREAST TUMOR-AMPLIFIED KINASE, SERINE/THREONINE-PROTEIN KINASE 15, SERINE/THREONINE-PROTEIN KINASE 6, SERINE/THREONINE-PROTEIN KINASE AURORA-A
2	C, D (A, B)	ethyl (9S)-9-[3-(1H-benzimidazol-2-yloxy)phenyl]-8-oxo-4,5,6,7,8,9-hexahydro-2H-pyrrolo[3,4-b]quinoline-3-carboxylate	non-polymer		468.5	2	Chemie (QMN)

Sequence modifications

A, B: 125 - 399 (UniProt: O14965)

PDB	External Database	Details
Met 124	-	expression tag
Ala 400	-	expression tag
Ala 401	-	expression tag
Ala 402	-	expression tag
Leu 403	-	expression tag
Glu 404	-	expression tag
His 405	-	expression tag
His 406	-	expression tag
His 407	-	expression tag
His 408	-	expression tag
His 409	-	expression tag
His 410	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	66656.4
Non-Polymers*	Number of molecules	2
	Total formula weight	937.0
All*	Total formula weight	67593.4

*Water molecules are not included.