4UZ6

STRUCTURE OF THE WNT DEACYLASE NOTUM - CRYSTAL FORM V - SOS COMPLEX - 1.9A

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	PROTEIN NOTUM HOMOLOG	polymer	383	43567.1	2	UniProt (Q6P988) Pfam (PF03283)	HOMO SAPIENS (HUMAN)
2	C, D (C, D)	1,3,4,6-tetra-O-sulfo-beta-D-fructofuranose-(2-1)-2,3,4,6-tetra-O-sulfonato-alpha-D-glucopyranose	branched		982.8	2	In PDB BIRD (PRD_900013)		sucrose octasulfate
3	E, G (A, B)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)
4	F, H (A, B)	CHLORIDE ION	non-polymer		35.5	2	Chemie (CL)
5	I, J (A, B)	water	water		18.0	204	Chemie (HOH)

Sequence modifications

A, B: 81 - 451 (UniProt: Q6P988)

PDB	External Database	Details
Glu 78	-	expression tag
Thr 79	-	expression tag
Gly 80	-	expression tag
Gly 452	-	expression tag
Thr 453	-	expression tag
Lys 454	-	expression tag
His 455	-	expression tag
His 456	-	expression tag
His 457	-	expression tag
His 458	-	expression tag
His 459	-	expression tag
His 460	-	expression tag
Ser 330	Cys 330	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	87134.3
Branched	Number of molecules	2
	Total formula weight	1965.6
Non-Polymers*	Number of molecules	4
	Total formula weight	513.3
All*	Total formula weight	89613.2

*Water molecules are not included.