4UYN
SAR156497 an exquisitely selective inhibitor of Aurora kinases
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | AURORA KINASE A | polymer | 287 | 33342.2 | 1 | UniProt (O14965) Pfam (PF00069) In PDB | HOMO SAPIENS (HUMAN) | AURORA 2, AURORA/IPL1-RELATED KINASE 1, ARK-1, AURORA-RELATED KINASE 1, HARK1, BREAST TUMOR-AMPLIFIED KINASE, SERINE/THREONINE-PROTEIN KINASE 15, SERINE/THREONINE-PROTEIN KINASE 6, SERINE/THREONINE-PROTEIN KINASE AURORA-A |
| 2 | A | ethyl (9S)-9-[5-(1H-benzimidazol-2-ylsulfanyl)furan-2-yl]-8-hydroxy-5,6,7,9-tetrahydro-2H-pyrrolo[3,4-b]quinoline-3-carboxylate | non-polymer | 474.5 | 1 | Chemie (Y3M) | |||
| 3 | water | water | 18.0 | 89 | Chemie (HOH) |
Sequence modifications
A: 125 - 399 (UniProt: O14965)
| PDB | External Database | Details |
|---|---|---|
| Met 124 | - | expression tag |
| Ala 400 | - | expression tag |
| Ala 401 | - | expression tag |
| Ala 402 | - | expression tag |
| Leu 403 | - | expression tag |
| Glu 404 | - | expression tag |
| His 405 | - | expression tag |
| His 406 | - | expression tag |
| His 407 | - | expression tag |
| His 408 | - | expression tag |
| His 409 | - | expression tag |
| His 410 | - | expression tag |
| Asp 288 | Thr 288 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 33342.2 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 474.5 | |
| All* | Total formula weight | 33816.7 |
