4UY0
Conserved mechanisms of microtubule-stimulated ADP release, ATP binding, and force generation in transport kinesins
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | TUBULIN ALPHA-1B CHAIN | polymer | 451 | 50107.2 | 1 | UniProt (P81947) Pfam (PF00091) Pfam (PF03953) | BOS TAURUS (CATTLE) | ALPHA-TUBULIN UBIQUITOUS, TUBULIN K-ALPHA-1 |
| 2 | B (B) | TUBULIN BETA-2B CHAIN | polymer | 426 | 47809.7 | 1 | UniProt (Q6B856) Pfam (PF00091) Pfam (PF03953) | BOS TAURUS (CATTLE) | |
| 3 | C (C) | KINESIN HEAVY CHAIN ISOFORM 5A | polymer | 340 | 38030.2 | 1 | UniProt (Q12840) Pfam (PF00225) | HOMO SAPIENS (HUMAN) | KINESIN HEAVY CHAIN NEURON-SPECIFIC 1, NEURONAL KINESIN HEAVY CHAIN, NKHC |
| 4 | D (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 5 | E, J (A, C) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) PubChem (888) | |||
| 6 | F (A) | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 1 | Chemie (GTP) PubChem (177679032) PubChem (135400627) PubChem (135487750) PubChem (136088935) PubChem (136803486) PubChem (135398633) PubChem (135544356) PubChem (135547949) PubChem (135600366) PubChem (135749822) PubChem (136005188) PubChem (136073923) PubChem (136240914) PubChem (136664747) PubChem (136772743) PubChem (136772744) PubChem (136803487) PubChem (137286749) PubChem (164715984) PubChem (171699466) | |||
| 7 | G (B) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 1 | Chemie (GDP) PubChem (136073927) PubChem (135398619) PubChem (135402030) PubChem (135431654) PubChem (135566337) PubChem (135760556) PubChem (136026707) PubChem (136053418) PubChem (136663964) PubChem (136664748) PubChem (136759848) PubChem (136759849) PubChem (136759850) PubChem (136836636) PubChem (136847074) PubChem (172898537) | |||
| 8 | H (B) | TAXOL | non-polymer | 853.9 | 1 | Chemie (TA1) PubChem (16757828) PubChem (16760674) PubChem (4666) PubChem (21458255) PubChem (23307219) PubChem (23412627) PubChem (23636632) PubChem (16760177) PubChem (16742549) PubChem (24848897) PubChem (24867246) PubChem (21733096) PubChem (23307242) PubChem (23307253) PubChem (23307913) PubChem (44323108) PubChem (44356961) PubChem (44403716) PubChem (24754091) PubChem (24207713) PubChem (24791027) PubChem (25200067) PubChem (42613129) PubChem (42620039) PubChem (44155032) PubChem (44276363) PubChem (46781469) PubChem (44279927) PubChem (44335735) PubChem (44291178) PubChem (44328863) PubChem (44342632) PubChem (44356895) PubChem (44378736) PubChem (49868078) PubChem (45489039) PubChem (46782671) PubChem (54259298) PubChem (71209844) PubChem (57908851) PubChem (57946364) PubChem (58803237) PubChem (53313247) PubChem (53298534) PubChem (54259297) PubChem (59844545) PubChem (54259299) PubChem (59904698) PubChem (60123443) PubChem (57489669) PubChem (57999380) PubChem (58460861) PubChem (58777027) PubChem (58798493) PubChem (58596717) PubChem (59048611) PubChem (59042813) PubChem (58877402) PubChem (60005248) PubChem (59873251) PubChem (59914794) PubChem (59919147) PubChem (60123436) PubChem (60011010) PubChem (60147315) PubChem (66795656) PubChem (70943371) PubChem (71096818) PubChem (5460441) PubChem (14060298) PubChem (176586897) PubChem (177678861) PubChem (73759783) PubChem (36314) PubChem (60915) PubChem (177409) PubChem (184492) PubChem (70801836) PubChem (70842048) PubChem (70848451) PubChem (70856170) PubChem (441276) PubChem (9854162) PubChem (73707502) PubChem (73759704) PubChem (9897470) PubChem (10033513) PubChem (10485732) PubChem (11506104) PubChem (89493063) PubChem (11828953) PubChem (89847578) PubChem (90057663) PubChem (91122402) PubChem (14060299) PubChem (14060304) PubChem (14060306) PubChem (14060309) PubChem (15983941) PubChem (91885464) PubChem (5317123) PubChem (5321715) PubChem (101920282) PubChem (5352019) PubChem (121459571) PubChem (122361554) PubChem (101598423) PubChem (6604028) PubChem (6604616) PubChem (6604814) PubChem (6713921) PubChem (6915727) PubChem (124747272) PubChem (124893098) PubChem (9875988) PubChem (126968948) PubChem (129395998) PubChem (129627423) PubChem (10748131) PubChem (132517454) PubChem (118528174) PubChem (11320430) PubChem (11354895) PubChem (134368714) PubChem (134972678) PubChem (124747271) PubChem (124747273) PubChem (124747274) PubChem (137705323) PubChem (138106885) PubChem (126761000) PubChem (140731501) PubChem (140512017) PubChem (133052515) PubChem (133640187) PubChem (146034004) PubChem (153289350) PubChem (154037993) PubChem (134715514) PubChem (155982214) PubChem (159121804) PubChem (160053861) PubChem (159716711) PubChem (160171678) PubChem (160585530) PubChem (163077211) PubChem (163077212) PubChem (163077209) PubChem (163284947) PubChem (143890766) PubChem (168322423) PubChem (152743329) PubChem (169917882) PubChem (171036874) PubChem (154828192) PubChem (144453087) PubChem (160585532) PubChem (175758871) PubChem (163077210) PubChem (163077213) PubChem (163077214) PubChem (163077215) PubChem (165084161) PubChem (166711459) PubChem (167423928) PubChem (170014955) PubChem (170362150) | |||
| 9 | I (C) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 1 | Chemie (ADP) | |||
| 10 | K (C) | TETRAFLUOROALUMINATE ION | non-polymer | 103.0 | 1 | Chemie (ALF) PubChem (5311325) | |||
| 11 | L (C) | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | non-polymer | 506.2 | 1 | Chemie (ANP) |
Sequence modifications
A: 0 - 424 (UniProt: P81947)
B: 1 - 426 (UniProt: Q6B856)
| PDB | External Database | Details |
|---|---|---|
| Ser 109 | Leu 136 | conflict |
| Gly 205 | Ser 232 | conflict |
| Gly 238 | Ile 265 | conflict |
| Thr 313 | Ser 340 | conflict |
| Glu 331 | Gln 358 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Ala 54 | Thr 55 | conflict |
| Val 169 | Met 170 | conflict |
| Ala 295 | Ser 296 | conflict |
| Val 315 | Ile 316 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 135947.2 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 2970.7 | |
| All* | Total formula weight | 138917.8 |
