4UY0
Conserved mechanisms of microtubule-stimulated ADP release, ATP binding, and force generation in transport kinesins
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | TUBULIN ALPHA-1B CHAIN | polymer | 451 | 50107.2 | 1 | UniProt (P81947) Pfam (PF00091) Pfam (PF03953) | BOS TAURUS (CATTLE) | ALPHA-TUBULIN UBIQUITOUS, TUBULIN K-ALPHA-1 |
| 2 | B (B) | TUBULIN BETA-2B CHAIN | polymer | 426 | 47809.7 | 1 | UniProt (Q6B856) Pfam (PF00091) Pfam (PF03953) | BOS TAURUS (CATTLE) | |
| 3 | C (C) | KINESIN HEAVY CHAIN ISOFORM 5A | polymer | 340 | 38030.2 | 1 | UniProt (Q12840) Pfam (PF00225) | HOMO SAPIENS (HUMAN) | KINESIN HEAVY CHAIN NEURON-SPECIFIC 1, NEURONAL KINESIN HEAVY CHAIN, NKHC |
| 4 | D (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 5 | E, J (A, C) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 6 | F (A) | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 1 | Chemie (GTP) | |||
| 7 | G (B) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 1 | Chemie (GDP) | |||
| 8 | H (B) | TAXOL | non-polymer | 853.9 | 1 | Chemie (TA1) | |||
| 9 | I (C) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 1 | Chemie (ADP) | |||
| 10 | K (C) | TETRAFLUOROALUMINATE ION | non-polymer | 103.0 | 1 | Chemie (ALF) | |||
| 11 | L (C) | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | non-polymer | 506.2 | 1 | Chemie (ANP) |
Sequence modifications
A: 0 - 424 (UniProt: P81947)
B: 1 - 426 (UniProt: Q6B856)
| PDB | External Database | Details |
|---|---|---|
| Ser 109 | Leu 136 | conflict |
| Gly 205 | Ser 232 | conflict |
| Gly 238 | Ile 265 | conflict |
| Thr 313 | Ser 340 | conflict |
| Glu 331 | Gln 358 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Ala 54 | Thr 55 | conflict |
| Val 169 | Met 170 | conflict |
| Ala 295 | Ser 296 | conflict |
| Val 315 | Ile 316 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 135947.2 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 2970.7 | |
| All* | Total formula weight | 138917.8 |
