4UXS

Conserved mechanisms of microtubule-stimulated ADP release, ATP binding, and force generation in transport kinesins

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	TUBULIN ALPHA-1B CHAIN	polymer	451	50107.2	1	UniProt (P81947) Pfam (PF00091) Pfam (PF03953) In PDB	BOS TAURUS (CATTLE)	ALPHA-TUBULIN UBIQUITOUS
2	B	TUBULIN BETA-2B CHAIN	polymer	445	49907.8	1	UniProt (Q6B856) Pfam (PF00091) Pfam (PF03953) In PDB	BOS TAURUS (CATTLE)
3	C	KINESIN-3 MOTOR DOMAIN	polymer	375	42088.3	1	UniProt (Q12756) Pfam (PF00225) In PDB	HOMO SAPIENS (HUMAN)
4	A	ZINC ION	non-polymer		65.4	1	Chemie (ZN)
5	A	MAGNESIUM ION	non-polymer		24.3	1	Chemie (MG)
6	A	GUANOSINE-5'-TRIPHOSPHATE	non-polymer		523.2	1	Chemie (GTP)
7	B	GUANOSINE-5'-DIPHOSPHATE	non-polymer		443.2	1	Chemie (GDP)
8	B	TAXOL	non-polymer		853.9	1	Chemie (TA1)

Sequence modifications

A: 0 - 424 (UniProt: P81947)

PDB	External Database	Details
Ser 109	Leu 136	conflict
Gly 205	Gly 232	conflict
Gly 238	Ile 265	conflict
Thr 313	Ser 340	conflict
Glu 331	Gln 358	conflict

B: 0 - 444 (UniProt: Q6B856)

PDB	External Database	Details
Val 169	Met 169	conflict
Val 315	Ile 315	conflict

C: -5 - 361 (UniProt: Q12756)

PDB	External Database	Details
Ser -5	-	expression tag
Asp -4	-	expression tag
Asn -3	-	expression tag
Ala -2	-	expression tag
Ile -1	-	expression tag
Ala 0	-	expression tag
His 362	-	expression tag
His 363	-	expression tag
His 364	-	expression tag
His 365	-	expression tag
His 366	-	expression tag
His 367	-	expression tag
His 368	-	expression tag
His 369	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	142103.3
Non-Polymers*	Number of molecules	5
	Total formula weight	1910.0
All*	Total formula weight	144013.3

*Water molecules are not included.