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4UXP

Conserved mechanisms of microtubule-stimulated ADP release, ATP binding, and force generation in transport kinesins

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)
TUBULIN ALPHA-1B CHAINpolymer45150107.21UniProt (P81947)
Pfam (PF00091)
Pfam (PF03953)
BOS TAURUS (CATTLE)ALPHA-TUBULIN UBIQUITOUS
2B
(B)
TUBULIN BETA-2B CHAINpolymer44549907.81UniProt (Q6B856)
Pfam (PF00091)
Pfam (PF03953)
BOS TAURUS (CATTLE)
3C
(C)
KINESIN-3 MOTOR DOMAINpolymer37542088.31UniProt (Q12756)
Pfam (PF00225)
HOMO SAPIENS (HUMAN)
4D
(A)
ZINC IONnon-polymer65.41Chemie (ZN)
5E, J
(A, C)
MAGNESIUM IONnon-polymer24.32Chemie (MG)
6F
(A)
GUANOSINE-5'-TRIPHOSPHATEnon-polymer523.21Chemie (GTP)
7G
(B)
GUANOSINE-5'-DIPHOSPHATEnon-polymer443.21Chemie (GDP)
8H
(B)
TAXOLnon-polymer853.91Chemie (TA1)
9I
(C)
PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTERnon-polymer506.21Chemie (ANP)
Sequence modifications
A: 0 - 424 (UniProt: P81947)
PDBExternal DatabaseDetails
Ser 109Leu 136conflict
Gly 205Gly 232conflict
Gly 238Ile 265conflict
Thr 313Ser 340conflict
Glu 331Gln 358conflict
B: 0 - 444 (UniProt: Q6B856)
PDBExternal DatabaseDetails
Val 169Met 169conflict
Val 315Ile 315conflict
C: -5 - 361 (UniProt: Q12756)
PDBExternal DatabaseDetails
Ser -5-expression tag
Asp -4-expression tag
Asn -3-expression tag
Ala -2-expression tag
Ile -1-expression tag
Ala 0-expression tag
His 362-expression tag
His 363-expression tag
His 364-expression tag
His 365-expression tag
His 366-expression tag
His 367-expression tag
His 368-expression tag
His 369-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains3
Total formula weight142103.3
Non-Polymers*Number of molecules7
Total formula weight2440.5
All*Total formula weight144543.8
*Water molecules are not included.

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PDB entries from 2024-11-20

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