4UXP
Conserved mechanisms of microtubule-stimulated ADP release, ATP binding, and force generation in transport kinesins
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A (A) | TUBULIN ALPHA-1B CHAIN | polymer | 451 | 50107.2 | 1 | UniProt (P81947) Pfam (PF00091) Pfam (PF03953) | BOS TAURUS (CATTLE) | ALPHA-TUBULIN UBIQUITOUS |
2 | B (B) | TUBULIN BETA-2B CHAIN | polymer | 445 | 49907.8 | 1 | UniProt (Q6B856) Pfam (PF00091) Pfam (PF03953) | BOS TAURUS (CATTLE) | |
3 | C (C) | KINESIN-3 MOTOR DOMAIN | polymer | 375 | 42088.3 | 1 | UniProt (Q12756) Pfam (PF00225) | HOMO SAPIENS (HUMAN) | |
4 | D (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
5 | E, J (A, C) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
6 | F (A) | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 1 | Chemie (GTP) | |||
7 | G (B) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 1 | Chemie (GDP) | |||
8 | H (B) | TAXOL | non-polymer | 853.9 | 1 | Chemie (TA1) | |||
9 | I (C) | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | non-polymer | 506.2 | 1 | Chemie (ANP) |
Sequence modifications
A: 0 - 424 (UniProt: P81947)
B: 0 - 444 (UniProt: Q6B856)
C: -5 - 361 (UniProt: Q12756)
PDB | External Database | Details |
---|---|---|
Ser 109 | Leu 136 | conflict |
Gly 205 | Gly 232 | conflict |
Gly 238 | Ile 265 | conflict |
Thr 313 | Ser 340 | conflict |
Glu 331 | Gln 358 | conflict |
PDB | External Database | Details |
---|---|---|
Val 169 | Met 169 | conflict |
Val 315 | Ile 315 | conflict |
PDB | External Database | Details |
---|---|---|
Ser -5 | - | expression tag |
Asp -4 | - | expression tag |
Asn -3 | - | expression tag |
Ala -2 | - | expression tag |
Ile -1 | - | expression tag |
Ala 0 | - | expression tag |
His 362 | - | expression tag |
His 363 | - | expression tag |
His 364 | - | expression tag |
His 365 | - | expression tag |
His 366 | - | expression tag |
His 367 | - | expression tag |
His 368 | - | expression tag |
His 369 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 142103.3 | |
Non-Polymers* | Number of molecules | 7 |
Total formula weight | 2440.5 | |
All* | Total formula weight | 144543.8 |