4UXL

Structure of Human ROS1 Kinase Domain in Complex with PF-06463922

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ROS	polymer	322	37014.5	1	UniProt (P08922) Pfam (PF07714) In PDB	HOMO SAPIENS (HUMAN)	PROTO-ONCOGENE C-ROS, PROTO-ONCOGENE C-ROS-1, RECEPTOR TYROSINE KINASE C-ROS ONCOGENE 1, C-ROS RECEPTOR TYROSINE KINASE
2	A	(10R)-7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile	non-polymer		406.4	1	Chemie (5P8)
3		water	water		18.0	136	Chemie (HOH)

Sequence modifications

A: 1934 - 2232 (UniProt: P08922)

PDB	External Database	Details
Met 1911	-	expression tag
Ala 1912	-	expression tag
His 1913	-	expression tag
His 1914	-	expression tag
His 1915	-	expression tag
His 1916	-	expression tag
His 1917	-	expression tag
His 1918	-	expression tag
Asp 1919	-	expression tag
Tyr 1920	-	expression tag
Gly 1921	-	expression tag
Ile 1922	-	expression tag
Pro 1923	-	expression tag
Thr 1924	-	expression tag
Thr 1925	-	expression tag
Glu 1926	-	expression tag
Asn 1927	-	expression tag
Leu 1928	-	expression tag
Tyr 1929	-	expression tag
Phe 1930	-	expression tag
Gln 1931	-	expression tag
Gly 1932	-	expression tag
Ser 1933	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	37014.5
Non-Polymers*	Number of molecules	1
	Total formula weight	406.4
All*	Total formula weight	37420.9

*Water molecules are not included.