4UWC
Fibroblast growth factor receptor 1 kinase in complex with JK-P3
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | FIBROBLAST GROWTH FACTOR RECEPTOR 1 | polymer | 309 | 35135.3 | 2 | UniProt (P11362) Pfam (PF07714) | Homo sapiens (human) | FGFR-1, BASIC FIBROBLAST GROWTH FACTOR RECEPTOR 1, BFGFR, B FGF-R-1, FMS-LIKE TYROSINE KINASE 2, FLT-2, N-SAM, PROTO-ONCOGENE C-FGR, FIBROBLAST GROWTH FACTOR RECEPTOR 1 KINASE |
| 2 | C, D, E, F, G... (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 12 | Chemie (EDO) | |||
| 3 | J, V (A, B) | 3,4-dimethoxy-N-(5-phenyl-1H-pyrazol-3-yl)benzamide | non-polymer | 323.3 | 2 | Chemie (4Y0) | |||
| 4 | K, L, W (A, B) | PROPANOIC ACID | non-polymer | 74.1 | 3 | Chemie (PPI) | |||
| 5 | M, N, O, P, X... (A, B) | SULFATE ION | non-polymer | 96.1 | 6 | Chemie (SO4) | |||
| 6 | AA, Z (B, A) | water | water | 18.0 | 339 | Chemie (HOH) |
Sequence modifications
A, B: 458 - 765 (UniProt: P11362)
| PDB | External Database | Details |
|---|---|---|
| Gly 457 | - | expression tag |
| Ala 488 | Cys 488 | engineered mutation |
| Ser 584 | Cys 584 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 70270.7 | |
| Non-Polymers* | Number of molecules | 23 |
| Total formula weight | 2190.1 | |
| All* | Total formula weight | 72460.8 |
