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4UVX

Crystal structure of human tankyrase 2 in complex with 3-(4- chlorophenyl)-5-fluoro-1,2-dihydroisoquinolin-1-one

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, BTANKYRASE-2polymer24027299.82UniProt (Q9H2K2)
Pfam (PF00644)
In PDB
HOMO SAPIENS (HUMAN)TANK2, ADP-RIBOSYLTRANSFERASE DIPHTHERIA TOXIN-LIKE 6, ARTD 6, POLY ADP-RIBOSE POLYMERASE 5B, TNKS-2, TRF1-INTERACTING ANKYRIN-RELATED ADP-RIBOSE POLYMERASE 2, TANKYRASE II, TANKYRASE-LIKE PROTEIN, TANKYRASE-RELATED PROTEIN
2A, BSULFATE IONnon-polymer96.14Chemie (SO4)
3AGLYCEROLnon-polymer92.12Chemie (GOL)
4A, BZINC IONnon-polymer65.42Chemie (ZN)
5A, B3-(4-chlorophenyl)-5-fluoroisoquinolin-1(2H)-onenon-polymer273.72Chemie (H2W)
6waterwater18.0256Chemie (HOH)
Sequence modifications
A, B: 946 - 1162 (UniProt: Q9H2K2)
PDBExternal DatabaseDetails
Met 923-expression tag
His 924-expression tag
His 925-expression tag
His 926-expression tag
His 927-expression tag
His 928-expression tag
His 929-expression tag
Ser 930-expression tag
Ser 931-expression tag
Gly 932-expression tag
Val 933-expression tag
Asp 934-expression tag
Leu 935-expression tag
Gly 936-expression tag
Thr 937-expression tag
Glu 938-expression tag
Asn 939-expression tag
Leu 940-expression tag
Tyr 941-expression tag
Phe 942-expression tag
Gln 943-expression tag
Ser 944-expression tag
Met 945-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight54599.5
Non-Polymers*Number of molecules10
Total formula weight1246.6
All*Total formula weight55846.2
*Water molecules are not included.

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PDB entries from 2024-03-27

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