4UTA
Crystal structure of dengue 2 virus envelope glycoprotein in complex with the Fab fragment of the broadly neutralizing human antibody EDE1 C8
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | ENVELOPE GLYCOPROTEIN E | polymer | 425 | 47231.0 | 2 | UniProt (Q68Y26) Pfam (PF00869) Pfam (PF02832) UniProt (by SIFTS) (A0A0B4SHY9) | DENGUE VIRUS 2 | E PROTEIN |
| 2 | C, D (H, I) | BROADLY NEUTRALIZING HUMAN ANTIBODY EDE1 C8 HEAVY CHAIN | polymer | 272 | 28882.8 | 2 | HOMO SAPIENS (HUMAN) | ||
| 3 | E, F (L, M) | BROADLY NEUTRALIZING HUMAN ANTIBODY EDE1 C8 LIGHT CHAIN | polymer | 217 | 23998.7 | 2 | HOMO SAPIENS (HUMAN) | ||
| 4 | G (C) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 732.7 | 1 | In PDB GlyTouCan (G32152BH) | |||
| 5 | H (D) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1057.0 | 1 | In PDB GlyTouCan (G82348BZ) | |||
| 6 | I, J, K, L, M... (A, B, H, I, L...) | water | water | 18.0 | 66 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 391 (UniProt: Q68Y26)
| PDB | External Database | Details |
|---|---|---|
| Leu 392 | - | expression tag |
| Arg 393 | - | expression tag |
| Pro 394 | - | expression tag |
| Leu 395 | - | expression tag |
| Glu 396 | - | expression tag |
| Ser 397 | - | expression tag |
| Arg 398 | - | expression tag |
| Gly 399 | - | expression tag |
| Pro 400 | - | expression tag |
| Phe 401 | - | expression tag |
| Glu 402 | - | expression tag |
| Gly 403 | - | expression tag |
| Lys 404 | - | expression tag |
| Pro 405 | - | expression tag |
| Ile 406 | - | expression tag |
| Pro 407 | - | expression tag |
| Asn 408 | - | expression tag |
| Pro 409 | - | expression tag |
| Leu 410 | - | expression tag |
| Leu 411 | - | expression tag |
| Gly 412 | - | expression tag |
| Leu 413 | - | expression tag |
| Asp 414 | - | expression tag |
| Ser 415 | - | expression tag |
| Thr 416 | - | expression tag |
| Arg 417 | - | expression tag |
| Thr 418 | - | expression tag |
| Gly 419 | - | expression tag |
| His 420 | - | expression tag |
| His 421 | - | expression tag |
| His 422 | - | expression tag |
| His 423 | - | expression tag |
| His 424 | - | expression tag |
| His 425 | - | expression tag |
| Lys 118 | Met 398 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 200225.0 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 1789.6 | |
| All* | Total formula weight | 202014.7 |
