4UQJ
Cryo-EM density map of GluA2em in complex with ZK200775
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | GLUTAMATE RECEPTOR 2 | polymer | 826 | 92523.6 | 4 | UniProt (P19491) Pfam (PF01094) Pfam (PF10613) Pfam (PF00060) | RATTUS NORVEGICUS (NORWAY RAT) | GLUR-2, AMPA-SELECTIVE GLUTAMATE RECEPTOR 2, GLUR-B, GLUR-K 2, GLUTAMATE RECEPTOR IONOTROPIC, AMPA 2, GLUA2, GLUA2 |
| 2 | E, F, G, H (A, B, C, D) | {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid | non-polymer | 409.3 | 4 | Chemie (ZK1) |
Sequence modifications
A, B, C, D: 7 - 826 (UniProt: P19491)
| PDB | External Database | Details |
|---|---|---|
| Glu 241 | Asn 256 | engineered mutation |
| Leu 382 | Val 397 | engineered mutation |
| Ala 589 | Cys 610 | engineered mutation |
| Leu 758 | Val 779 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 370094.5 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1637.0 | |
| All* | Total formula weight | 371731.5 |
