4UN0

Crystal structure of the human CDK12-cyclinK complex

Replaces:  4CJY

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	CYCLIN-K	polymer	259	30443.1	2	UniProt (O75909) Pfam (PF00134) Pfam (PF21797)	HOMO SAPIENS (HUMAN)	CCNK
2	C, D (C, D)	CYCLIN-DEPENDENT KINASE 12	polymer	326	37819.7	2	UniProt (Q9NYV4) Pfam (PF00069)	HOMO SAPIENS (HUMAN)	CDC2-RELATED KINASE, ARGININE/SERINE-RICH, CRKRS, CELL DIVISION CYCLE 2-RELATED PROTEIN KINASE 7, CDC2-RELATED PROTEIN KINASE 7, CELL DIVISION PROTEIN KINASE 12, HCDK12, CDK12

Sequence modifications

A, B: 11 - 267 (UniProt: O75909)

PDB	External Database	Details
Ser 9	-	expression tag
Met 10	-	expression tag

C, D: 715 - 1038 (UniProt: Q9NYV4)

PDB	External Database	Details
Ser 713	-	expression tag
Met 714	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	136525.6
All*	Total formula weight	136525.6

*Water molecules are not included.