4UMX
IDH1 R132H in complex with cpd 1
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | ISOCITRATE DEHYDROGENASE [NADP] CYTOPLASMIC | polymer | 425 | 48135.7 | 2 | UniProt (O75874) Pfam (PF00180) In PDB | HOMO SAPIENS (HUMAN) | IDH, CYTOSOLIC NADP-ISOCITRATE DEHYDROGENASE, IDP, NADP(+)- SPECIFIC ICDH, OXALOSUCCINATE DECARBOXYLASE |
2 | A | 2,6-bis(1H-imidazol-1-ylmethyl)-4-(2,4,4-trimethylpentan-2-yl)phenol | non-polymer | 366.5 | 1 | Chemie (VVS) | |||
3 | A, B | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 2 | Chemie (NAP) | |||
4 | B | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
5 | water | water | 18.0 | 766 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 414 (UniProt: O75874)
PDB | External Database | Details |
---|---|---|
Ser 415 | - | expression tag |
Leu 416 | - | expression tag |
Glu 417 | - | expression tag |
His 418 | - | expression tag |
His 419 | - | expression tag |
His 420 | - | expression tag |
His 421 | - | expression tag |
His 422 | - | expression tag |
His 423 | - | expression tag |
His 424 | - | expression tag |
His 425 | - | expression tag |
His 132 | Arg 132 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 96271.4 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 1945.4 | |
All* | Total formula weight | 98216.8 |