4UMO
Crystal Structure of the Kv7.1 proximal C-terminal Domain in Complex with Calmodulin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 1 | polymer | 112 | 13438.2 | 2 | UniProt (P51787) | HOMO SAPIENS (HUMAN) | KV7.1 CHANNEL, IKS PRODUCING SLOW VOLTAGE-GATED POTASSIUM CHANNEL SUBUNIT ALPHA KVLQT1, KQT-LIKE 1, VOLTAGE-GATED POTASSIUM CHANNEL SUBUNIT KV7.1 |
| 2 | C, D (C, D) | CALMODULIN | polymer | 149 | 16852.5 | 2 | UniProt (P62158) Pfam (PF13499) UniProt (by SIFTS) (P0DP23) | HOMO SAPIENS (HUMAN) | CAM |
| 3 | E, F, H, K (A, B, C) | POTASSIUM ION | non-polymer | 39.1 | 4 | Chemie (K) | |||
| 4 | G (A) | THIOCYANATE ION | non-polymer | 58.1 | 1 | Chemie (SCN) | |||
| 5 | I, J, L, M (C, D) | CALCIUM ION | non-polymer | 40.1 | 4 | Chemie (CA) | |||
| 6 | N (D) | water | water | 18.0 | 1 | Chemie (HOH) |
Sequence modifications
A, B: 352 - 396 (UniProt: P51787)
A, B: 397 - 539 (UniProt: P51787)
| PDB | External Database | Details |
|---|---|---|
| Met 323 | - | expression tag |
| Gly 324 | - | expression tag |
| Ser 325 | - | expression tag |
| His 326 | - | expression tag |
| His 327 | - | expression tag |
| His 328 | - | expression tag |
| His 329 | - | expression tag |
| His 330 | - | expression tag |
| His 331 | - | expression tag |
| His 332 | - | expression tag |
| His 333 | - | expression tag |
| Gly 334 | - | expression tag |
| Ser 335 | - | expression tag |
| Asp 336 | - | expression tag |
| Tyr 337 | - | expression tag |
| Asp 338 | - | expression tag |
| Asp 339 | - | expression tag |
| Ile 340 | - | expression tag |
| Pro 341 | - | expression tag |
| Thr 342 | - | expression tag |
| Thr 343 | - | expression tag |
| Glu 344 | - | expression tag |
| Asn 345 | - | expression tag |
| Leu 346 | - | expression tag |
| Tyr 347 | - | expression tag |
| Phe 348 | - | expression tag |
| Gln 349 | - | expression tag |
| Gly 350 | - | expression tag |
| Ser 351 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Glu 397 | His 502 | engineered mutation |
| Phe 398 | Ile 503 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 60581.5 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 374.8 | |
| All* | Total formula weight | 60956.3 |
