4UMN
Structure of a stapled peptide antagonist bound to Nutlin-resistant Mdm2.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | E3 ubiquitin-protein ligase Mdm2 | polymer | 120 | 13535.4 | 2 | UniProt (Q00987) Pfam (PF02201) | Homo sapiens (human) | Double minute 2 protein,Hdm2,Oncoprotein Mdm2,RING-type E3 ubiquitin transferase Mdm2,p53-binding protein Mdm2 |
| 2 | C, D (C, D) | M06 | polymer | 13 | 1541.8 | 2 | SYNTHETIC CONSTRUCT | ||
| 3 | E, F, G, H (A, B, C, D) | water | water | 18.0 | 85 | Chemie (HOH) |
Sequence modifications
A, B: 6 - 125 (UniProt: Q00987)
| PDB | External Database | Details |
|---|---|---|
| Ala 62 | Met 62 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 30154.5 | |
| All* | Total formula weight | 30154.5 |
