4UIX
N-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH 7-(3,4-dimethoxyphenyl)-N-(1,1-dioxo-1-thian-4-yl)-5-methyl-4-oxo-4H,5H-thieno-3,2-c-pyridine-2- carboxamide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | BROMODOMAIN-CONTAINING PROTEIN 4 | polymer | 127 | 15100.4 | 3 | UniProt (O60885) Pfam (PF00439) | HOMO SAPIENS (HUMAN) | PROTEIN HUNK1, NHUMAN BRD4 |
| 2 | D, G (A, B) | CALCIUM ION | non-polymer | 40.1 | 2 | Chemie (CA) | |||
| 3 | E, H, J (A, B, C) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 3 | Chemie (EDO) | |||
| 4 | F, I, K (A, B, C) | N-[1,1-bis(oxidanylidene)thian-4-yl]-7-(3,4-dimethoxyphenyl)-5-methyl-4-oxidanylidene-thieno[3,2-c]pyridine-2-carboxamide | non-polymer | 476.6 | 3 | Chemie (TVU) | |||
| 5 | L, M, N (A, B, C) | water | water | 18.0 | 428 | Chemie (HOH) |
Sequence modifications
A, B, C: 44 - 168 (UniProt: O60885)
| PDB | External Database | Details |
|---|---|---|
| Ser 42 | - | expression tag |
| Met 43 | - | expression tag |
| Lys 78 | Gln 78 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 45301.3 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1696.1 | |
| All* | Total formula weight | 46997.4 |
