4UIP

The complex structure of extracellular domain of EGFR with Repebody (rAC1).

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	EPIDERMAL GROWTH FACTOR RECEPTOR	polymer	618	68587.0	1	UniProt (P00533) Pfam (PF01030) Pfam (PF00757) Pfam (PF14843) In PDB	HOMO SAPIENS (HUMAN)	PROTO-ONCOGENE C-ERBB-1, RECEPTOR TYROSINE-PROTEIN KINASE E RBB-1
2	B	REPEBODY (RAC1)	polymer	251	28303.2	1	UniProt (E0ACT6) UniProt (Q4G1L3) Pfam (PF11921) Pfam (PF12354) Pfam (PF13855) In PDB	LISTERIA MONOCYTOGENES
3	C	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	1	In PDB GlyTouCan (G42666HT)
4	A	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)
5		water	water		18.0	41	Chemie (HOH)

Sequence modifications

A: 2 - 613 (UniProt: P00533)

PDB	External Database	Details
His 614	-	expression tag
His 615	-	expression tag
His 616	-	expression tag
His 617	-	expression tag
His 618	-	expression tag
His 619	-	expression tag

B: 2 - 66 (UniProt: E0ACT6)

PDB	External Database	Details
Met 1	-	expression tag
Ala 25	Asp 56	conflict
Leu 244	-	expression tag
Glu 245	-	expression tag
His 246	-	expression tag
His 247	-	expression tag
His 248	-	expression tag
His 249	-	expression tag
His 250	-	expression tag
His 251	-	expression tag

B: 67 - 151 (PDB: 4UIP)
B: 152 - 243 (UniProt: Q4G1L3)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	96890.2
Branched	Number of molecules	1
	Total formula weight	424.4
Non-Polymers*	Number of molecules	2
	Total formula weight	442.4
All*	Total formula weight	97757.0

*Water molecules are not included.