4UI9
Atomic structure of the human Anaphase-Promoting Complex
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | ANAPHASE-PROMOTING COMPLEX SUBUNIT 1 | polymer | 1944 | 216777.7 | 1 | UniProt (Q9H1A4) Pfam (PF12859) Pfam (PF20518) Pfam (PF21282) Pfam (PF18122) In PDB | HOMO SAPIENS (HUMAN) | APC1, CYCLOSOME SUBUNIT 1, MITOTIC CHECKPOINT REGULATOR, TESTIS-SPECIFIC GENE 24 PROTEIN, APC1, CYCLOSOME SUBUNIT 1, MITOTIC CHECKPOINT REGULATOR, TESTIS-SPECIFIC GENE 24 PROTEIN |
2 | B | ANAPHASE-PROMOTING COMPLEX SUBUNIT 11 | polymer | 84 | 9866.7 | 1 | UniProt (Q9NYG5) Pfam (PF12861) In PDB | HOMO SAPIENS (HUMAN) | APC11, CYCLOSOME SUBUNIT 11, HEPATOCELLULAR CARCINOMA-ASSOCIATED RING FINGER PROTEIN, APC11, CYCLOSOME SUBUNIT 11, HEPATOCELLULAR CARCINOMA- ASSOCIATED RING FINGER PROTEIN |
3 | C, P | CELL DIVISION CYCLE PROTEIN 23 HOMOLOG | polymer | 591 | 68356.4 | 2 | UniProt (Q9UJX2) Pfam (PF04049) In PDB | HOMO SAPIENS (HUMAN) | ANAPHASE-PROMOTING COMPLEX SUBUNIT 8, APC8, CYCLOSOME SUBUNIT 8, ANAPHASE-PROMOTING COMPLEX SUBUNIT 8, APC8, CYCLOSOME SUBUNIT 8 |
4 | D | ANAPHASE-PROMOTING COMPLEX SUBUNIT 15 | polymer | 121 | 14302.7 | 1 | UniProt (P60006) Pfam (PF15243) In PDB | HOMO SAPIENS (HUMAN) | APC15, APC15 |
5 | E | ANAPHASE-PROMOTING COMPLEX SUBUNIT 16 | polymer | 110 | 11678.0 | 1 | UniProt (Q96DE5) Pfam (PF17256) In PDB | HOMO SAPIENS (HUMAN) | APC16, CYCLOSOME SUBUNIT 16, APC16, CYCLOSOME SUBUNIT 16 |
6 | F, H | CELL DIVISION CYCLE PROTEIN 27 HOMOLOG | polymer | 824 | 92005.1 | 2 | UniProt (P30260) Pfam (PF12895) Pfam (PF00515) In PDB | HOMO SAPIENS (HUMAN) | ANAPHASE-PROMOTING COMPLEX SUBUNIT 3, APC3, CDC27 HOMOLOG, CDC27HS, H-NUC, ANAPHASE-PROMOTING COMPLEX SUBUNIT 3, APC3, CDC27 HOMOLOG, CDC27HS, H-NUC |
7 | G | ANAPHASE-PROMOTING COMPLEX SUBUNIT CDC26 | polymer | 85 | 9808.0 | 1 | UniProt (Q8NHZ8) Pfam (PF10471) In PDB | HOMO SAPIENS (HUMAN) | ANAPHASE-PROMOTING COMPLEX SUBUNIT 12, APC12, CELL DIVISION CYCLE PROTEIN 26 HOMOLOG, ANAPHASE-PROMOTING COMPLEX SUBUNIT 12, APC12, CELL DIVISION CYCLE PROTEIN 26 HOMOLOG |
8 | I | ANAPHASE-PROMOTING COMPLEX SUBUNIT 4 | polymer | 808 | 92205.2 | 1 | UniProt (Q9UJX5) Pfam (PF12894) Pfam (PF12896) In PDB | HOMO SAPIENS (HUMAN) | APC4, CYCLOSOME SUBUNIT 4, APC4, CYCLOSOME SUBUNIT 4 |
9 | J | CELL DIVISION CYCLE PROTEIN 16 HOMOLOG | polymer | 620 | 71747.6 | 1 | UniProt (Q13042) Pfam (PF12895) Pfam (PF13424) In PDB | HOMO SAPIENS (HUMAN) | ANAPHASE-PROMOTING COMPLEX SUBUNIT 6, APC6, CDC16 HOMOLOG, CDC16HS, CYCLOSOME SUBUNIT 6, ANAPHASE-PROMOTING COMPLEX SUBUNIT 6, APC6, CDC16 HOMOLOG, CDC16HS, CYCLOSOME SUBUNIT 6 |
10 | K | CELL DIVISION CYCLE PROTEIN 16 HOMOLOG | polymer | 620 | 71806.7 | 1 | UniProt (Q13042) Pfam (PF12895) Pfam (PF13424) In PDB | HOMO SAPIENS (HUMAN) | ANAPHASE-PROMOTING COMPLEX SUBUNIT 6, APC6, CDC16 HOMOLOG, CDC16HS, CYCLOSOME SUBUNIT 6, ANAPHASE-PROMOTING COMPLEX SUBUNIT 6, APC6, CDC16 HOMOLOG, CDC16HS, CYCLOSOME SUBUNIT 6 |
11 | L | ANAPHASE-PROMOTING COMPLEX SUBUNIT 10 | polymer | 183 | 21021.8 | 1 | UniProt (Q9UM13) Pfam (PF03256) In PDB | HOMO SAPIENS (HUMAN) | APC10, CYCLOSOME SUBUNIT 10, APC10, CYCLOSOME SUBUNIT 10 |
12 | M | ANAPHASE-PROMOTING COMPLEX SUBUNIT 13 | polymer | 74 | 8528.3 | 1 | UniProt (Q9BS18) Pfam (PF05839) In PDB | HOMO SAPIENS (HUMAN) | APC13, CYCLOSOME SUBUNIT 13, APC13, CYCLOSOME SUBUNIT 13 |
13 | N | ANAPHASE-PROMOTING COMPLEX SUBUNIT 2 | polymer | 822 | 93939.0 | 1 | UniProt (Q9UJX6) Pfam (PF00888) Pfam (PF08672) In PDB | HOMO SAPIENS (HUMAN) | APC2, CYCLOSOME SUBUNIT 2, APC2, CYCLOSOME SUBUNIT 2 |
14 | O | ANAPHASE-PROMOTING COMPLEX SUBUNIT 5 | polymer | 756 | 85216.7 | 1 | UniProt (Q9UJX4) Pfam (PF21371) Pfam (PF12862) In PDB | HOMO SAPIENS (HUMAN) | APC5, CYCLOSOME SUBUNIT 5, APC5, CYCLOSOME SUBUNIT 5 |
15 | R | FIZZY-RELATED PROTEIN HOMOLOG | polymer | 493 | 54838.7 | 1 | UniProt (Q9UM11) Pfam (PF12894) Pfam (PF00400) In PDB | HOMO SAPIENS (HUMAN) | FZR, CDC20-LIKE PROTEIN 1, CDH1/HCT1 HOMOLOG, HCDH1, FZR, C DC20-LIKE PROTEIN 1, CDH1/HCT1 HOMOLOG, HCDH1 |
16 | S | F-BOX ONLY PROTEIN 5 | polymer | 447 | 50297.6 | 1 | UniProt (Q9UKT4) Pfam (PF00646) Pfam (PF22191) In PDB | HOMO SAPIENS (HUMAN) | EARLY MITOTIC INHIBITOR 1, EARLY MITOTIC INHIBITOR 1 |
17 | T | PEPTIDE | polymer | 21 | 1609.8 | 1 | HOMO SAPIENS (HUMAN) | ||
18 | U | PEPTIDE | polymer | 24 | 2258.7 | 1 | UniProt (by SIFTS) (Q9UKT4) In PDB | HOMO SAPIENS (HUMAN) | |
19 | W | ANAPHASE-PROMOTING COMPLEX SUBUNIT CDC26 | polymer | 85 | 9794.0 | 1 | UniProt (Q8NHZ8) Pfam (PF10471) In PDB | HOMO SAPIENS (HUMAN) | ANAPHASE-PROMOTING COMPLEX SUBUNIT 12, APC12, CELL DIVISION CYCLE PROTEIN 26 HOMOLOG, ANAPHASE-PROMOTING COMPLEX SUBUNIT 12, APC12, CELL DIVISION CYCLE PROTEIN 26 HOMOLOG |
20 | X, Y | ANAPHASE-PROMOTING COMPLEX SUBUNIT 7 | polymer | 565 | 63106.8 | 2 | UniProt (Q9UJX3) Pfam (PF13181) Pfam (PF13432) In PDB | HOMO SAPIENS (HUMAN) | APC7, CYCLOSOME SUBUNIT 7, APC7, CYCLOSOME SUBUNIT 7 |
21 | S, B | ZINC ION | non-polymer | 65.4 | 5 | Chemie (ZN) |
Sequence modifications
A: 1 - 1947 (UniProt: Q9H1A4)
B: 1 - 84 (UniProt: Q9NYG5)
C, P: 7 - 597 (UniProt: Q9UJX2)
D: 1 - 121 (UniProt: P60006)
F, H: 1 - 861 (UniProt: P30260)
G: 1 - 85 (UniProt: Q8NHZ8)
I: 1 - 808 (UniProt: Q9UJX5)
J: 1 - 620 (UniProt: Q13042)
K: 1 - 620 (UniProt: Q13042)
L: 2 - 184 (UniProt: Q9UM13)
N: 1 - 822 (UniProt: Q9UJX6)
O: 1 - 755 (UniProt: Q9UJX4)
S: 1 - 447 (UniProt: Q9UKT4)
X, Y: 35 - 599 (UniProt: Q9UJX3)
PDB | External Database | Details |
---|---|---|
Phe 291 | Thr 291 | conflict |
Ile 940 | Thr 940 | conflict |
Glu 1059 | Asp 1059 | conflict |
Leu 1358 | Ile 1358 | conflict |
Leu 1637 | Thr 1637 | conflict |
Pro 1880 | Leu 1877 | conflict |
Leu 1881 | Glu 1878 | conflict |
PDB | External Database | Details |
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Leu 13 | Thr 13 | conflict |
PDB | External Database | Details |
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Leu 161 | Lys 161 | conflict |
PDB | External Database | Details |
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Tyr 5 | Phe 5 | conflict |
PDB | External Database | Details |
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Glu 403 | Lys 403 | conflict |
Ser 475 | Ala 475 | conflict |
Ser 484 | Ala 484 | conflict |
PDB | External Database | Details |
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Glu 14 | Asp 14 | conflict |
PDB | External Database | Details |
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Asp 430 | Glu 430 | conflict |
PDB | External Database | Details |
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Asn 225 | Asp 225 | conflict |
Glu 228 | Gln 228 | conflict |
Lys 229 | Glu 229 | conflict |
PDB | External Database | Details |
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Glu 228 | Gln 228 | conflict |
Lys 229 | Glu 229 | conflict |
Lys 265 | Ala 265 | conflict |
PDB | External Database | Details |
---|---|---|
- | Glu 163 | deletion |
PDB | External Database | Details |
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Ile 410 | Leu 410 | conflict |
PDB | External Database | Details |
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Ser 42 | Asn 42 | conflict |
Val 55 | Met 55 | conflict |
Gln 63 | Leu 63 | conflict |
Val 75 | Leu 75 | conflict |
Leu 79 | Tyr 79 | conflict |
Ser 164 | Asn 164 | conflict |
Asp 165 | Gly 165 | conflict |
Asn 167 | - | insertion |
PDB | External Database | Details |
---|---|---|
Ile 323 | Thr 323 | conflict |
Lys 326 | Ala 326 | conflict |
PDB | External Database | Details |
---|---|---|
Leu 63 | Met 63 | conflict |
Leu 142 | Met 142 | conflict |
Val 148 | Met 148 | conflict |
Asn 466 | Asp 466 | conflict |
Glu 472 | Arg 472 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 23 |
Total formula weight | 1272633.7 | |
Non-Polymers* | Number of molecules | 5 |
Total formula weight | 327.0 | |
All* | Total formula weight | 1272960.8 |