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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

4UI9

Atomic structure of the human Anaphase-Promoting Complex

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)		ANAPHASE-PROMOTING COMPLEX SUBUNIT 1polymer1944216777.71UniProt (Q9H1A4)
Pfam (PF12859)
Pfam (PF20518)
Pfam (PF21282)
Pfam (PF18122)		HOMO SAPIENS (HUMAN)APC1, CYCLOSOME SUBUNIT 1, MITOTIC CHECKPOINT REGULATOR, TESTIS-SPECIFIC GENE 24 PROTEIN, APC1, CYCLOSOME SUBUNIT 1, MITOTIC CHECKPOINT REGULATOR, TESTIS-SPECIFIC GENE 24 PROTEIN
2B
(B)		ANAPHASE-PROMOTING COMPLEX SUBUNIT 11polymer849866.71UniProt (Q9NYG5)
Pfam (PF12861)		HOMO SAPIENS (HUMAN)APC11, CYCLOSOME SUBUNIT 11, HEPATOCELLULAR CARCINOMA-ASSOCIATED RING FINGER PROTEIN, APC11, CYCLOSOME SUBUNIT 11, HEPATOCELLULAR CARCINOMA- ASSOCIATED RING FINGER PROTEIN
3C, P
(C, P)		CELL DIVISION CYCLE PROTEIN 23 HOMOLOGpolymer59168356.42UniProt (Q9UJX2)
Pfam (PF04049)		HOMO SAPIENS (HUMAN)ANAPHASE-PROMOTING COMPLEX SUBUNIT 8, APC8, CYCLOSOME SUBUNIT 8, ANAPHASE-PROMOTING COMPLEX SUBUNIT 8, APC8, CYCLOSOME SUBUNIT 8
4D
(D)		ANAPHASE-PROMOTING COMPLEX SUBUNIT 15polymer12114302.71UniProt (P60006)
Pfam (PF15243)		HOMO SAPIENS (HUMAN)APC15, APC15
5E
(E)		ANAPHASE-PROMOTING COMPLEX SUBUNIT 16polymer11011678.01UniProt (Q96DE5)
Pfam (PF17256)		HOMO SAPIENS (HUMAN)APC16, CYCLOSOME SUBUNIT 16, APC16, CYCLOSOME SUBUNIT 16
6F, H
(F, H)		CELL DIVISION CYCLE PROTEIN 27 HOMOLOGpolymer82492005.12UniProt (P30260)
Pfam (PF12895)
Pfam (PF00515)		HOMO SAPIENS (HUMAN)ANAPHASE-PROMOTING COMPLEX SUBUNIT 3, APC3, CDC27 HOMOLOG, CDC27HS, H-NUC, ANAPHASE-PROMOTING COMPLEX SUBUNIT 3, APC3, CDC27 HOMOLOG, CDC27HS, H-NUC
7G
(G)		ANAPHASE-PROMOTING COMPLEX SUBUNIT CDC26polymer859808.01UniProt (Q8NHZ8)
Pfam (PF10471)		HOMO SAPIENS (HUMAN)ANAPHASE-PROMOTING COMPLEX SUBUNIT 12, APC12, CELL DIVISION CYCLE PROTEIN 26 HOMOLOG, ANAPHASE-PROMOTING COMPLEX SUBUNIT 12, APC12, CELL DIVISION CYCLE PROTEIN 26 HOMOLOG
8I
(I)		ANAPHASE-PROMOTING COMPLEX SUBUNIT 4polymer80892205.21UniProt (Q9UJX5)
Pfam (PF12894)
Pfam (PF12896)		HOMO SAPIENS (HUMAN)APC4, CYCLOSOME SUBUNIT 4, APC4, CYCLOSOME SUBUNIT 4
9J
(J)		CELL DIVISION CYCLE PROTEIN 16 HOMOLOGpolymer62071747.61UniProt (Q13042)
Pfam (PF12895)
Pfam (PF13424)		HOMO SAPIENS (HUMAN)ANAPHASE-PROMOTING COMPLEX SUBUNIT 6, APC6, CDC16 HOMOLOG, CDC16HS, CYCLOSOME SUBUNIT 6, ANAPHASE-PROMOTING COMPLEX SUBUNIT 6, APC6, CDC16 HOMOLOG, CDC16HS, CYCLOSOME SUBUNIT 6
10K
(K)		CELL DIVISION CYCLE PROTEIN 16 HOMOLOGpolymer62071806.71UniProt (Q13042)
Pfam (PF12895)
Pfam (PF13424)		HOMO SAPIENS (HUMAN)ANAPHASE-PROMOTING COMPLEX SUBUNIT 6, APC6, CDC16 HOMOLOG, CDC16HS, CYCLOSOME SUBUNIT 6, ANAPHASE-PROMOTING COMPLEX SUBUNIT 6, APC6, CDC16 HOMOLOG, CDC16HS, CYCLOSOME SUBUNIT 6
11L
(L)		ANAPHASE-PROMOTING COMPLEX SUBUNIT 10polymer18321021.81UniProt (Q9UM13)
Pfam (PF03256)		HOMO SAPIENS (HUMAN)APC10, CYCLOSOME SUBUNIT 10, APC10, CYCLOSOME SUBUNIT 10
12M
(M)		ANAPHASE-PROMOTING COMPLEX SUBUNIT 13polymer748528.31UniProt (Q9BS18)
Pfam (PF05839)		HOMO SAPIENS (HUMAN)APC13, CYCLOSOME SUBUNIT 13, APC13, CYCLOSOME SUBUNIT 13
13N
(N)		ANAPHASE-PROMOTING COMPLEX SUBUNIT 2polymer82293939.01UniProt (Q9UJX6)
Pfam (PF00888)
Pfam (PF08672)		HOMO SAPIENS (HUMAN)APC2, CYCLOSOME SUBUNIT 2, APC2, CYCLOSOME SUBUNIT 2
14O
(O)		ANAPHASE-PROMOTING COMPLEX SUBUNIT 5polymer75685216.71UniProt (Q9UJX4)
Pfam (PF21371)
Pfam (PF12862)		HOMO SAPIENS (HUMAN)APC5, CYCLOSOME SUBUNIT 5, APC5, CYCLOSOME SUBUNIT 5
15Q
(R)		FIZZY-RELATED PROTEIN HOMOLOGpolymer49354838.71UniProt (Q9UM11)
Pfam (PF12894)
Pfam (PF00400)		HOMO SAPIENS (HUMAN)FZR, CDC20-LIKE PROTEIN 1, CDH1/HCT1 HOMOLOG, HCDH1, FZR, C DC20-LIKE PROTEIN 1, CDH1/HCT1 HOMOLOG, HCDH1
16R
(S)		F-BOX ONLY PROTEIN 5polymer44750297.61UniProt (Q9UKT4)
Pfam (PF00646)
Pfam (PF22191)		HOMO SAPIENS (HUMAN)EARLY MITOTIC INHIBITOR 1, EARLY MITOTIC INHIBITOR 1
17S
(T)		PEPTIDEpolymer211609.81HOMO SAPIENS (HUMAN)
18T
(U)		PEPTIDEpolymer242258.71UniProt (by SIFTS) (Q9UKT4)HOMO SAPIENS (HUMAN)
19U
(W)		ANAPHASE-PROMOTING COMPLEX SUBUNIT CDC26polymer859794.01UniProt (Q8NHZ8)
Pfam (PF10471)		HOMO SAPIENS (HUMAN)ANAPHASE-PROMOTING COMPLEX SUBUNIT 12, APC12, CELL DIVISION CYCLE PROTEIN 26 HOMOLOG, ANAPHASE-PROMOTING COMPLEX SUBUNIT 12, APC12, CELL DIVISION CYCLE PROTEIN 26 HOMOLOG
20V, W
(X, Y)		ANAPHASE-PROMOTING COMPLEX SUBUNIT 7polymer56563106.82UniProt (Q9UJX3)
Pfam (PF13181)
Pfam (PF13432)		HOMO SAPIENS (HUMAN)APC7, CYCLOSOME SUBUNIT 7, APC7, CYCLOSOME SUBUNIT 7
21AA, BA, X, Y, Z
(S, B)		ZINC IONnon-polymer65.45Chemie (ZN)
Sequence modifications
A: 1 - 1947 (UniProt: Q9H1A4)
PDBExternal DatabaseDetails
Phe 291Thr 291conflict
Ile 940Thr 940conflict
Glu 1059Asp 1059conflict
Leu 1358Ile 1358conflict
Leu 1637Thr 1637conflict
Pro 1880Leu 1877conflict
Leu 1881Glu 1878conflict
B: 1 - 84 (UniProt: Q9NYG5)
PDBExternal DatabaseDetails
Leu 13Thr 13conflict
C, P: 7 - 597 (UniProt: Q9UJX2)
PDBExternal DatabaseDetails
Leu 161Lys 161conflict
D: 1 - 121 (UniProt: P60006)
PDBExternal DatabaseDetails
Tyr 5Phe 5conflict
F, H: 1 - 861 (UniProt: P30260)
PDBExternal DatabaseDetails
Glu 403Lys 403conflict
Ser 475Ala 475conflict
Ser 484Ala 484conflict
G: 1 - 85 (UniProt: Q8NHZ8)
PDBExternal DatabaseDetails
Glu 14Asp 14conflict
I: 1 - 808 (UniProt: Q9UJX5)
PDBExternal DatabaseDetails
Asp 430Glu 430conflict
J: 1 - 620 (UniProt: Q13042)
PDBExternal DatabaseDetails
Asn 225Asp 225conflict
Glu 228Gln 228conflict
Lys 229Glu 229conflict
K: 1 - 620 (UniProt: Q13042)
PDBExternal DatabaseDetails
Glu 228Gln 228conflict
Lys 229Glu 229conflict
Lys 265Ala 265conflict
L: 2 - 184 (UniProt: Q9UM13)
PDBExternal DatabaseDetails
-Glu 163deletion
N: 1 - 822 (UniProt: Q9UJX6)
PDBExternal DatabaseDetails
Ile 410Leu 410conflict
O: 1 - 755 (UniProt: Q9UJX4)
PDBExternal DatabaseDetails
Ser 42Asn 42conflict
Val 55Met 55conflict
Gln 63Leu 63conflict
Val 75Leu 75conflict
Leu 79Tyr 79conflict
Ser 164Asn 164conflict
Asp 165Gly 165conflict
Asn 167-insertion
S: 1 - 447 (UniProt: Q9UKT4)
PDBExternal DatabaseDetails
Ile 323Thr 323conflict
Lys 326Ala 326conflict
X, Y: 35 - 599 (UniProt: Q9UJX3)
PDBExternal DatabaseDetails
Leu 63Met 63conflict
Leu 142Met 142conflict
Val 148Met 148conflict
Asn 466Asp 466conflict
Glu 472Arg 472conflict
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains23
Total formula weight1272633.7
Non-Polymers*Number of molecules5
Total formula weight327.0
All*Total formula weight1272960.8
*Water molecules are not included.

246031

PDB entries from 2025-12-10

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