4UI1

Crystal structure of the human RGMC-BMP2 complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	BONE MORPHOGENETIC PROTEIN 2	polymer	114	12923.9	2	UniProt (P12643) Pfam (PF00019) In PDB	HOMO SAPIENS (HUMAN)	BMP-2, BONE MORPHOGENETIC PROTEIN 2A, BMP-2A, BMP2
2	C, D	HEMOJUVELIN	polymer	122	12432.0	2	UniProt (Q6ZVN8) Pfam (PF06535) In PDB	HOMO SAPIENS (HUMAN)	HEMOCHROMATOSIS TYPE 2 PROTEIN, RGM DOMAIN FAMILY MEMBER C, REPULSIVE GUIDANCE MOLECULE C, RGMC
3	A, B, D	NITRATE ION	non-polymer		62.0	6	Chemie (NO3)
4	A	CHLORIDE ION	non-polymer		35.5	2	Chemie (CL)
5	B, C, D	1,2-ETHANEDIOL	non-polymer		62.1	3	Chemie (EDO)
6		water	water		18.0	85	Chemie (HOH)

Sequence modifications

C, D: 35 - 145 (UniProt: Q6ZVN8)

PDB	External Database	Details
Glu 33	-	expression tag
Thr 34	-	expression tag
Gly 146	-	expression tag
Thr 147	-	expression tag
Lys 148	-	expression tag
His 149	-	expression tag
His 150	-	expression tag
His 151	-	expression tag
His 152	-	expression tag
His 153	-	expression tag
His 154	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	50711.7
Non-Polymers*	Number of molecules	11
	Total formula weight	629.1
All*	Total formula weight	51340.9

*Water molecules are not included.