4UFZ
Synthesis of Novel NAD Dependant DNA Ligase Inhibitors via Negishi Cross-Coupling: Development of SAR and Resistance Studies
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | DNA LIGASE | polymer | 324 | 36513.3 | 1 | UniProt (P43813) Pfam (PF01653) | HAEMOPHILUS INFLUENZAE | POLYDEOXYRIBONUCLEOTIDE SYNTHASE NAD(+), NAD DEPENDENT DNA LIGASE |
| 2 | B (A) | 5,7-bis(azanyl)-2-tert-butyl-4-(1,3-thiazol-2-yl)pyrido[2,3-d]pyrimidine-6-carbonitrile | non-polymer | 325.4 | 1 | Chemie (IA7) | |||
| 3 | C (A) | 1-(2,4-dimethylbenzyl)-6-oxo-1,6-dihydropyridine-3-carboxamide | non-polymer | 256.3 | 1 | Chemie (IWH) | |||
| 4 | D (A) | water | water | 18.0 | 157 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 36513.3 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 581.7 | |
| All* | Total formula weight | 37095.0 |
