4UCK

X-ray structure and activities of an essential Mononegavirales L- protein domain

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	RNA-DIRECTED RNA POLYMERASE L	polymer	415	47661.1	2	UniProt (Q91L20) Pfam (PF14314)	HUMAN METAPNEUMOVIRUS	LARGE STRUCTURAL PROTEIN
2	C, E (A, B)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
3	D, F (A, B)	S-ADENOSYLMETHIONINE	non-polymer		398.4	2	Chemie (SAM)
4	G, H (A, B)	water	water		18.0	155	Chemie (HOH)

Sequence modifications

A, B: 1600 - 2005 (UniProt: Q91L20)

PDB	External Database	Details
Met 1599	-	expression tag
Ser 2006	-	expression tag
Gly 2007	-	expression tag
His 2008	-	expression tag
His 2009	-	expression tag
His 2010	-	expression tag
His 2011	-	expression tag
His 2012	-	expression tag
His 2013	-	expression tag
Glu 1995	Lys 1995	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	95322.2
Non-Polymers*	Number of molecules	4
	Total formula weight	927.7
All*	Total formula weight	96249.9

*Water molecules are not included.