4UA4
Structure of the VIM-2 Metallo-beta-Lactamase in Complex with a Bisthiazolidine Inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Beta-lactamase class B VIM-2 | polymer | 242 | 25693.5 | 2 | UniProt (Q9K2N0) Pfam (PF00753) | Pseudomonas aeruginosa | Class B beta-lactamase,Metallo beta-lactamase,Metallo-beta-lactamase,Metallo-beta-lactamase VIM-2,Mettalo-beta-lactamase VIM-2,VIM-2,VIM-2 class B metallo b-lactamase,VIM-2 protein,VIM-2 type metallo-beta-lactamase |
| 2 | C, D, I, J (A, B) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 3 | E, K, L, M (A, B) | GLYCEROL | non-polymer | 92.1 | 4 | Chemie (GOL) | |||
| 4 | F, G, H (A, B) | (3R,5R,7aS)-5-(sulfanylmethyl)tetrahydro[1,3]thiazolo[4,3-b][1,3]thiazole-3-carboxylic acid | non-polymer | 237.4 | 3 | Chemie (3C7) | |||
| 5 | N, O (A, B) | water | water | 18.0 | 355 | Chemie (HOH) |
Sequence modifications
A, B: 25 - 264 (UniProt: Q9K2N0)
| PDB | External Database | Details |
|---|---|---|
| Gly 23 | - | expression tag |
| Pro 24 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 51387.0 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 1342.1 | |
| All* | Total formula weight | 52729.1 |
