4U97
Crystal Structure of Asymmetric IRAK4 Dimer
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Interleukin-1 receptor-associated kinase 4 | polymer | 312 | 34820.5 | 2 | UniProt (Q9NWZ3) Pfam (PF07714) | Homo sapiens (Human) | IRAK-4,Renal carcinoma antigen NY-REN-64 |
| 2 | C, D (A, B) | STAUROSPORINE | non-polymer | 466.5 | 2 | Chemie (STU) | |||
| 3 | E, F, G (B) | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
| 4 | H, I (A, B) | water | water | 18.0 | 97 | Chemie (HOH) |
Sequence modifications
A, B: 154 - 460 (UniProt: Q9NWZ3)
| PDB | External Database | Details |
|---|---|---|
| Gly 149 | - | expression tag |
| Ala 150 | - | expression tag |
| Met 151 | - | expression tag |
| Gly 152 | - | expression tag |
| Ser 153 | - | expression tag |
| Asn 311 | Asp 311 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 69640.9 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1221.3 | |
| All* | Total formula weight | 70862.2 |
