4U97
Crystal Structure of Asymmetric IRAK4 Dimer
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Interleukin-1 receptor-associated kinase 4 | polymer | 312 | 34820.5 | 2 | UniProt (Q9NWZ3) Pfam (PF07714) | Homo sapiens (Human) | IRAK-4,Renal carcinoma antigen NY-REN-64 |
| 2 | C, D (A, B) | STAUROSPORINE | non-polymer | 466.5 | 2 | Chemie (STU) PubChem (5279) PubChem (44259) PubChem (71203703) PubChem (42610657) PubChem (44299148) PubChem (25322871) PubChem (28684983) PubChem (451705) PubChem (44120114) PubChem (44537813) PubChem (49831000) PubChem (46864193) PubChem (68262703) PubChem (68306294) PubChem (5459111) PubChem (73953205) PubChem (6419748) PubChem (86306248) PubChem (358479) PubChem (9804568) PubChem (9937179) PubChem (5280487) PubChem (5311103) PubChem (6711321) PubChem (9956178) PubChem (122130844) PubChem (12046017) PubChem (143163481) PubChem (143224059) PubChem (143494026) PubChem (162978898) | |||
| 3 | E, F, G (B) | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
| 4 | H, I (A, B) | water | water | 18.0 | 97 | Chemie (HOH) |
Sequence modifications
A, B: 154 - 460 (UniProt: Q9NWZ3)
| PDB | External Database | Details |
|---|---|---|
| Gly 149 | - | expression tag |
| Ala 150 | - | expression tag |
| Met 151 | - | expression tag |
| Gly 152 | - | expression tag |
| Ser 153 | - | expression tag |
| Asn 311 | Asp 311 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 69640.9 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1221.3 | |
| All* | Total formula weight | 70862.2 |
