4U5F
Crystal structure of GluA2, con-ikot-ikot snail toxin, partial agonist KA and postitive modulator (R,R)-2b complex, GluA2cryst2 construct
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Glutamate receptor 2 | polymer | 814 | 91184.1 | 4 | UniProt (P19491) Pfam (PF01094) Pfam (PF10613) Pfam (PF00060) | Rattus norvegicus (Rat) | GluR-2,AMPA-selective glutamate receptor 2,GluR-B,GluR-K2,Glutamate receptor ionotropic,AMPA 2,GluA2 |
| 2 | E, F (E, F) | Con-ikot-ikot | polymer | 90 | 9753.2 | 2 | UniProt (P0CB20) | Conus striatus (Striated cone) | |
| 3 | G, J, L, O (A, B, C, D) | 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE | non-polymer | 213.2 | 4 | Chemie (KAI) PubChem (3816) PubChem (10255) PubChem (73345) PubChem (3083828) PubChem (5317452) PubChem (5318769) PubChem (6453379) PubChem (6604705) PubChem (10036135) PubChem (11095940) PubChem (23616889) PubChem (45039619) PubChem (6603893) PubChem (101994997) PubChem (135037246) | |||
| 4 | H, K, M, P (A, B, C, D) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 4 | Chemie (NAG) | |||
| 5 | I, N (B, D) | N,N'-[biphenyl-4,4'-diyldi(2R)propane-2,1-diyl]dipropane-2-sulfonamide | non-polymer | 480.7 | 2 | Chemie (FWF) PubChem (22259901) PubChem (44468130) PubChem (44468131) |
Sequence modifications
A, B, C, D: 6 - 824 (UniProt: P19491)
E, F: 1 - 86 (UniProt: P0CB20)
| PDB | External Database | Details |
|---|---|---|
| Gly 184 | Lys 203 | engineered mutation |
| Glu 237 | Asn 256 | engineered mutation |
| - | Leu 402 | deletion |
| - | Pro 403 | deletion |
| Asp 385 | Asn 406 | engineered mutation |
| Gln 392 | Asn 413 | engineered mutation |
| - | Arg 581 | deletion |
| - | Glu 582 | deletion |
| - | Thr 583 | deletion |
| - | Gln 584 | deletion |
| - | Ser 585 | deletion |
| Glu 565 | Ser 586 | engineered mutation |
| Ala 589 | Cys 610 | engineered mutation |
| Ala 815 | Cys 836 | engineered mutation |
| Arg 818 | Ser 839 | engineered mutation |
| Met 819 | Arg 840 | engineered mutation |
| Lys 820 | Ala 841 | engineered mutation |
| Leu 821 | Glu 842 | engineered mutation |
| Val 822 | Ala 843 | engineered mutation |
| Pro 823 | Lys 844 | engineered mutation |
| - | Met 846 | deletion |
| - | Lys 847 | deletion |
| - | Val 848 | deletion |
| PDB | External Database | Details |
|---|---|---|
| Gly -3 | - | expression tag |
| Pro -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 384242.5 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 2699.1 | |
| All* | Total formula weight | 386941.6 |
