4U5F
Crystal structure of GluA2, con-ikot-ikot snail toxin, partial agonist KA and postitive modulator (R,R)-2b complex, GluA2cryst2 construct
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D | Glutamate receptor 2 | polymer | 814 | 91184.1 | 4 | UniProt (P19491) Pfam (PF01094) Pfam (PF10613) Pfam (PF00060) In PDB | Rattus norvegicus (Rat) | GluR-2,AMPA-selective glutamate receptor 2,GluR-B,GluR-K2,Glutamate receptor ionotropic,AMPA 2,GluA2 |
| 2 | E, F | Con-ikot-ikot | polymer | 90 | 9753.2 | 2 | UniProt (P0CB20) In PDB | Conus striatus (Striated cone) | |
| 3 | A, B, C, D | 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE | non-polymer | 213.2 | 4 | Chemie (KAI) | |||
| 4 | A, B, C, D | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 4 | Chemie (NAG) | |||
| 5 | B, D | N,N'-[biphenyl-4,4'-diyldi(2R)propane-2,1-diyl]dipropane-2-sulfonamide | non-polymer | 480.7 | 2 | Chemie (FWF) |
Sequence modifications
A, B, C, D: 6 - 824 (UniProt: P19491)
E, F: 1 - 86 (UniProt: P0CB20)
| PDB | External Database | Details |
|---|---|---|
| Gly 184 | Lys 203 | engineered mutation |
| Glu 237 | Asn 256 | engineered mutation |
| - | Leu 402 | deletion |
| - | Pro 403 | deletion |
| Asp 385 | Asn 406 | engineered mutation |
| Gln 392 | Asn 413 | engineered mutation |
| - | Arg 581 | deletion |
| - | Glu 582 | deletion |
| - | Thr 583 | deletion |
| - | Gln 584 | deletion |
| - | Ser 585 | deletion |
| Glu 565 | Ser 586 | engineered mutation |
| Ala 589 | Cys 610 | engineered mutation |
| Ala 815 | Cys 836 | engineered mutation |
| Arg 818 | Ser 839 | engineered mutation |
| Met 819 | Arg 840 | engineered mutation |
| Lys 820 | Ala 841 | engineered mutation |
| Leu 821 | Glu 842 | engineered mutation |
| Val 822 | Ala 843 | engineered mutation |
| Pro 823 | Lys 844 | engineered mutation |
| - | Met 846 | deletion |
| - | Lys 847 | deletion |
| - | Val 848 | deletion |
| PDB | External Database | Details |
|---|---|---|
| Gly -3 | - | expression tag |
| Pro -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 384242.5 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 2699.1 | |
| All* | Total formula weight | 386941.6 |
