4U5D

Crystal structure of GluA2, con-ikot-ikot snail toxin, partial agonist KA and postitive modulator (R,R)-2b complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	Glutamate receptor 2	polymer	814	91385.3	4	UniProt (P19491) Pfam (PF01094) Pfam (PF10613) Pfam (PF00060) Pfam (PF00497) In PDB	Rattus norvegicus (Rat)	GluR-2,AMPA-selective glutamate receptor 2,GluR-B,GluR-K2,Glutamate receptor ionotropic,AMPA 2,GluA2
2	E, F	Con-ikot-ikot	polymer	90	9753.2	2	UniProt (P0CB20) In PDB	Conus striatus (Striated cone)
3	A, B, C, D	3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE	non-polymer		213.2	4	Chemie (KAI)
4	A, B, C, D	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	4	Chemie (NAG)
5	A, B	N,N'-[biphenyl-4,4'-diyldi(2R)propane-2,1-diyl]dipropane-2-sulfonamide	non-polymer		480.7	2	Chemie (FWF)

Sequence modifications

A, B, C, D: 6 - 824 (UniProt: P19491)

PDB	External Database	Details
Gly 184	Lys 203	engineered mutation
Glu 237	Asn 256	engineered mutation
-	Leu 402	deletion
-	Pro 403	deletion
Asp 385	Asn 406	engineered mutation
Gln 392	Asn 413	engineered mutation
Asp 461	Asn 482	engineered mutation
Ala 528	Cys 549	engineered mutation
Leu 535	Gly 556	engineered mutation
-	Arg 581	deletion
-	Glu 582	deletion
-	Thr 583	deletion
-	Gln 584	deletion
-	Ser 585	deletion
Glu 565	Ser 586	engineered mutation
Phe 577	Leu 598	engineered mutation
Ala 580	Ser 601	engineered mutation
Lys 582	Gly 603	engineered mutation
Leu 583	Ala 604	engineered mutation
Phe 585	Met 606	engineered mutation
Ala 589	Cys 610	engineered mutation
Ala 598	Gly 619	engineered mutation
Ala 602	Gly 623	engineered mutation
Ala 815	Cys 836	engineered mutation
Arg 818	Ser 839	engineered mutation
Met 819	Arg 840	engineered mutation
Lys 820	Ala 841	engineered mutation
Leu 821	Glu 842	engineered mutation
Val 822	Ala 843	engineered mutation
Pro 823	Lys 844	engineered mutation

E, F: 1 - 86 (UniProt: P0CB20)

PDB	External Database	Details
Gly -3	-	expression tag
Pro -2	-	expression tag
Gly -1	-	expression tag
Ser 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	385047.6
Non-Polymers*	Number of molecules	10
	Total formula weight	2699.1
All*	Total formula weight	387746.7

*Water molecules are not included.