4U3T

Crystal structure of the transpeptidase domain of Neisseria gonorrhoeae penicillin-binding protein 2 derived from the penicillin-resistant strain 6140

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Penicillin-binding protein 2	polymer	330	35411.3	2	UniProt (P08149) Pfam (PF00905)	Neisseria gonorrhoeae FA6140	PBP-2
2	C, D (A, B)	water	water		18.0	92	Chemie (HOH)

Sequence modifications

A, B: 237 - 574 (UniProt: P08149)

PDB	External Database	Details
Gly 232	-	expression tag
Ser 233	-	expression tag
Gly 234	-	expression tag
Gly 235	-	expression tag
Ala 236	-	expression tag
-	Ala 283	deletion
-	Tyr 284	deletion
-	Asp 285	deletion
-	Pro 286	deletion
-	Asn 287	deletion
-	Arg 288	deletion
-	Pro 289	deletion
-	Gly 290	deletion
-	Arg 291	deletion
-	Ala 292	deletion
-	Asp 293	deletion
-	Ser 294	deletion
-	Glu 295	deletion
-	Gln 296	deletion
Gly 297	Arg 297	conflict
Asp 346	-	insertion
Leu 504	Phe 504	engineered mutation
Val 510	Ala 510	engineered mutation
Gly 516	Ala 516	engineered mutation
Ser 551	Pro 551	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	70822.6
All*	Total formula weight	70822.6

*Water molecules are not included.