4U0I
Crystal structure of KIT in complex with ponatinib
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Mast/stem cell growth factor receptor Kit,Mast/stem cell growth factor receptor Kit | polymer | 315 | 35616.2 | 1 | UniProt (P10721) Pfam (PF07714) | Homo sapiens (Human) | SCFR,Piebald trait protein,PBT,Proto-oncogene c-Kit,Tyrosine-protein kinase Kit,p145 c-kit,v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog,SCFR,Piebald trait protein,PBT,Proto-oncogene c-Kit,Tyrosine-protein kinase Kit,p145 c-kit,v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog |
| 2 | B (A) | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzam ide | non-polymer | 532.6 | 1 | Chemie (0LI) | |||
| 3 | C, D (A) | PHOSPHATE ION | non-polymer | 95.0 | 2 | Chemie (PO4) | |||
| 4 | E (A) | water | water | 18.0 | 137 | Chemie (HOH) |
Sequence modifications
A: 563 - 751 (UniProt: P10721)
A: 754 - 935 (UniProt: P10721)
A: 754 - 935 (UniProt: P10721)
| PDB | External Database | Details |
|---|---|---|
| Thr 752 | - | linker |
| Ser 753 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 35616.2 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 722.5 | |
| All* | Total formula weight | 36338.7 |
