4TWN

Human EphA3 Kinase domain in complex with Birb796

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Ephrin type-A receptor 3	polymer	361	40458.2	1	UniProt (P29320) Pfam (PF07714) Pfam (PF07647) In PDB	Homo sapiens (Human)	EPH-like kinase 4,hEK4,HEK,Human embryo kinase,Tyrosine-protein kinase TYRO4,Tyrosine-protein kinase receptor ETK1,Eph-like tyrosine kinase 1
2	A	1-(5-TERT-BUTYL-2-P-TOLYL-2H-PYRAZOL-3-YL)-3-[4-(2-MORPHOLIN-4-YL-ETHOXY)-NAPHTHALEN-1-YL]-UREA	non-polymer		527.7	1	Chemie (B96)
3		water	water		18.0	178	Chemie (HOH)

Sequence modifications

A: 609 - 947 (UniProt: P29320)

PDB	External Database	Details
Met 587	-	initiating methionine
Gly 588	-	expression tag
Ser 589	-	expression tag
Ser 590	-	expression tag
His 591	-	expression tag
His 592	-	expression tag
His 593	-	expression tag
His 594	-	expression tag
His 595	-	expression tag
His 596	-	expression tag
Ser 597	-	expression tag
Ser 598	-	expression tag
Gly 599	-	expression tag
Leu 600	-	expression tag
Val 601	-	expression tag
Pro 602	-	expression tag
Arg 603	-	expression tag
Gly 604	-	expression tag
Ser 605	-	expression tag
Thr 606	-	expression tag
Gln 607	-	expression tag
Thr 608	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	40458.2
Non-Polymers*	Number of molecules	1
	Total formula weight	527.7
All*	Total formula weight	40985.8

*Water molecules are not included.