4TWC
2-Benzamido-N-(1H-benzo[d]imidazol-2-yl)thiazole-4- carboxamide derivatives as potent inhibitors of CK1d/e
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Casein kinase I isoform delta | polymer | 295 | 34310.6 | 2 | UniProt (P48730) Pfam (PF00069) | Homo sapiens (Human) | CKId,Tau-protein kinase CSNK1D |
| 2 | C, D, E, F, K... (A, B) | SULFATE ION | non-polymer | 96.1 | 8 | Chemie (SO4) | |||
| 3 | G, O, P (A, B) | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
| 4 | H, J (A) | octyl beta-D-glucopyranoside | non-polymer | 292.4 | 2 | Chemie (BOG) | |||
| 5 | I, R (A, B) | 2-{[2-(trifluoromethoxy)benzoyl]amino}-N-[6-(trifluoromethyl)-1H-benzimidazol-2-yl]-1,3-thiazole-4-carboxamide | non-polymer | 515.4 | 2 | Chemie (37J) | |||
| 6 | Q (B) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) | |||
| 7 | S, T (A, B) | water | water | 18.0 | 837 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 295 (UniProt: P48730)
| PDB | External Database | Details |
|---|---|---|
| Asn 13 | Arg 13 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 68621.2 | |
| Non-Polymers* | Number of molecules | 16 |
| Total formula weight | 2738.4 | |
| All* | Total formula weight | 71359.7 |
