4TVP
Crystal Structure of the HIV-1 BG505 SOSIP.664 Env Trimer Ectodomain, Comprising Atomic-Level Definition of Pre-Fusion gp120 and gp41, in Complex with Human Antibodies PGT122 and 35O22
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | G | Envelope glycoprotein gp160 | polymer | 481 | 54064.3 | 1 | UniProt (Q2N0S5) Pfam (PF00516) In PDB | Human immunodeficiency virus 1 | |
2 | B | Envelope glycoprotein gp160 | polymer | 153 | 17146.5 | 1 | UniProt (Q2N0S5) Pfam (PF00517) In PDB | Human immunodeficiency virus 1 | |
3 | L | PGT122 Light chain | polymer | 213 | 22880.3 | 1 | Homo sapiens (human) | ||
4 | H | PGT122 Heavy chain | polymer | 235 | 25434.7 | 1 | Homo sapiens (human) | ||
5 | D | 35O22 Heavy chain | polymer | 243 | 26170.5 | 1 | Homo sapiens (human) | ||
6 | E | 35O22 Light chain | polymer | 216 | 23318.8 | 1 | Homo sapiens (human) | ||
7 | A | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1235.1 | 1 | In PDB GlyTouCan (G55220VL) | |||
8 | C | alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 1 | In PDB GlyTouCan (G81315DD) | |||
9 | F, J, K, M, P... | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 8 | In PDB GlyTouCan (G42666HT) | |||
10 | I | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1073.0 | 1 | In PDB GlyTouCan (G56014GC) | |||
11 | N | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G15407YE) | |||
12 | O | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 1 | In PDB GlyTouCan (G22768VO) | |||
13 | T | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1721.5 | 1 | In PDB GlyTouCan (G91704UR) | |||
14 | B, H, G | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 8 | Chemie (NAG) | |||
15 | G, B, L | SULFATE ION | non-polymer | 96.1 | 10 | Chemie (SO4) | |||
16 | water | water | 18.0 | 37 | Chemie (HOH) |
Sequence modifications
G: 31 - 508 (UniProt: Q2N0S5)
B: 512 - 664 (UniProt: Q2N0S5)
PDB | External Database | Details |
---|---|---|
Asn 332 | Thr 330 | engineered mutation |
Cys 501 | Ala 498 | engineered mutation |
Arg 509 | - | expression tag |
Arg 510 | - | expression tag |
Arg 511 | - | expression tag |
Arg 512 | - | expression tag |
Arg 513 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Pro 559 | Ile 556 | engineered mutation |
Cys 605 | Thr 602 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 169015.1 | |
Branched | Number of molecules | 14 |
Total formula weight | 9670.9 | |
Non-Polymers* | Number of molecules | 18 |
Total formula weight | 2730.3 | |
All* | Total formula weight | 181416.2 |