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4TVH

HIV Protease (PR) dimer in closed form with TL-3 in active site and fragment AK-2097 in the outside/top of flap

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, BProteasepolymer9910831.82UniProt (Q90EA1)
Pfam (PF00077)
In PDB
Human immunodeficiency virus 1
2Abenzyl [(1S,4S,7S,8R,9R,10S,13S,16S)-7,10-dibenzyl-8,9-dihydroxy-1,16-dimethyl-4,13-bis(1-methylethyl)-2,5,12,15,18-pentaoxo-20-phenyl-19-oxa-3,6,11,14,17-pentaazaicos-1-yl]carbamatenon-polymer909.11BIRD (PRD_000434)
Chemie (3TL)
3BBETA-MERCAPTOETHANOLnon-polymer78.11Chemie (BME)
4B3-(morpholin-4-ylmethyl)-1H-indole-6-carboxylic acidnon-polymer260.31Chemie (K97)
5waterwater18.059Chemie (HOH)
Sequence modifications
A, B: 1 - 99 (UniProt: Q90EA1)
PDBExternal DatabaseDetails
Lys 7Gln 7engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight21663.7
Non-Polymers*Number of molecules3
Total formula weight1247.5
All*Total formula weight22911.2
*Water molecules are not included.

225158

PDB entries from 2024-09-18

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