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4TUR

Human DNA polymerase beta inserting dCMPNPP opposite the 5'G of cisplatin crosslinked Gs (Pt-GG2)

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)
DNA polymerase betapolymer32937536.81UniProt (P06746)
Pfam (PF14716)
Pfam (PF10391)
Pfam (PF14792)
Pfam (PF14791)
Homo sapiens (Human)
2B
(T)
DNA (5'-D(*CP*CP*CP*AP*CP*GP*GP*CP*CP*CP*AP*TP*CP*AP*CP*C)-3')polymer164749.11Homo sapiens
3C
(P)
DNA (5'-D(*GP*GP*TP*GP*AP*TP*GP*GP*GP*C)-3')polymer103141.11Homo sapiens
4D
(D)
DNA (5'-D(P*GP*TP*GP*GP*G)-3')polymer51576.11Homo sapiens
5E, F
(A)
MAGNESIUM IONnon-polymer24.32Chemie (MG)
6G, H
(A)
SODIUM IONnon-polymer23.02Chemie (NA)
7I
(A)
2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]cytidinenon-polymer466.21Chemie (0KX)
8J
(T)
Cisplatinnon-polymer300.01Chemie (CPT)
9K, L, M, N
(A, T, P, D)
waterwater18.0145Chemie (HOH)
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains4
Total formula weight47003.0
Non-Polymers*Number of molecules6
Total formula weight860.8
All*Total formula weight47863.8
*Water molecules are not included.

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PDB entries from 2025-06-11

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