4TUH
Bcl-xL in complex with inhibitor (Compound 10)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | Bcl-2-like protein 1 | polymer | 158 | 17918.0 | 8 | UniProt (Q07817) Pfam (PF02180) Pfam (PF00452) | Homo sapiens (Human) | Bcl2-L-1,Apoptosis regulator Bcl-X |
| 2 | AA, CA, I, Q, S... (G, H, A, B, C...) | 2-[8-(1,3-benzothiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl]-5-{3-[4-(1H-pyrazolo[3,4-d]pyrimidin-1-yl)phenoxy]propyl}-1,3-thiazole-4-carboxylic acid | non-polymer | 688.8 | 8 | Chemie (38H) | |||
| 3 | BA, DA, EA, J, K... (G, H, A, C, F) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 14 | Chemie (EDO) | |||
| 4 | R (B) | ACETATE ION | non-polymer | 59.0 | 1 | Chemie (ACT) | |||
| 5 | FA, GA, HA, IA, JA... (A, B, C, D, E...) | water | water | 18.0 | 856 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F, G, H: 1 - 26 (UniProt: Q07817)
A, B, C, D, E, F, G, H: 83 - 209 (UniProt: Q07817)
| PDB | External Database | Details |
|---|---|---|
| Gly -4 | - | expression tag |
| Pro -3 | - | expression tag |
| Leu -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 143343.7 | |
| Non-Polymers* | Number of molecules | 23 |
| Total formula weight | 6438.2 | |
| All* | Total formula weight | 149781.9 |
