4TT8

Crystal structure of the hydrolase domain of 10-formyltetrahydrofolate dehydrogenase (wild-type) complex with 10-formyl-5,8-dideazafolate

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	10-formyltetrahydrofolate dehydrogenase	polymer	318	35456.4	1	UniProt (E3NZ06) Pfam (PF00551) Pfam (PF02911) In PDB	Danio rerio (Zebrafish)
2	A	N-(4-{[(2-amino-4-hydroxyquinazolin-6-yl)methyl](formyl)amino}benzoyl)-L-glutamic acid	non-polymer		467.4	1	Chemie (6DD)
3	A	2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL	non-polymer		209.2	1	Chemie (BTB)
4		water	water		18.0	162	Chemie (HOH)

Sequence modifications

A: 1 - 311 (UniProt: E3NZ06)

PDB	External Database	Details
Glu 312	-	expression tag
His 313	-	expression tag
His 314	-	expression tag
His 315	-	expression tag
His 316	-	expression tag
His 317	-	expression tag
His 318	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	35456.4
Non-Polymers*	Number of molecules	2
	Total formula weight	676.7
All*	Total formula weight	36133.1

*Water molecules are not included.