4TPW
The co-complex structure of the translation initiation factor eIF4E with the inhibitor 4EGI-1 reveals an allosteric mechanism for dissociating eIF4G
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Eukaryotic translation initiation factor 4E | polymer | 191 | 22290.3 | 2 | UniProt (P06730) Pfam (PF01652) | Homo sapiens (Human) | eIF4E,eIF-4F 25 kDa subunit,mRNA cap-binding protein |
| 2 | C, E (A, B) | 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 538.2 | 2 | Chemie (MGP) | |||
| 3 | D (A) | (2E)-2-{2-[4-(3,4-dichlorophenyl)-1,3-thiazol-2-yl]hydrazinylidene}-3-(2-nitrophenyl)propanoic acid | non-polymer | 451.3 | 1 | Chemie (33R) | |||
| 4 | F (B) | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | non-polymer | 195.2 | 1 | Chemie (MES) | |||
| 5 | G, H (A, B) | water | water | 18.0 | 424 | Chemie (HOH) |
Sequence modifications
A, B: 28 - 217 (UniProt: P06730)
| PDB | External Database | Details |
|---|---|---|
| Met 27 | - | initiating methionine |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 44580.7 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1723.0 | |
| All* | Total formula weight | 46303.6 |
