4TO3
Structural basis of cellular dNTP regulation, SAMHD1-dGTP-dGTP-dCTP complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | polymer | 514 | 59604.2 | 4 | UniProt (Q9Y3Z3) Pfam (PF01966) | Homo sapiens (Human) | dNTPase, Dendritic cell-derived IFNG-induced protein, DCIP, Monocyte protein 5, MOP-5, SAM domain and HD domain-containing protein 1 |
| 2 | E, K, R, V (A, B, C, D) | 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE | non-polymer | 467.2 | 4 | Chemie (DCP) | |||
| 3 | F, I, J, L, Q... (A, B, C, D) | MAGNESIUM ION | non-polymer | 24.3 | 8 | Chemie (MG) | |||
| 4 | G, H, M, N, O... (A, B, C, D) | 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 8 | Chemie (DGT) | |||
| 5 | AA, BA, Y, Z (C, D, A, B) | water | water | 18.0 | 490 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 113 - 626 (UniProt: Q9Y3Z3)
| PDB | External Database | Details |
|---|---|---|
| Arg 206 | His 206 | engineered mutation |
| Asn 207 | Asp 207 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 238416.7 | |
| Non-Polymers* | Number of molecules | 20 |
| Total formula weight | 6120.5 | |
| All* | Total formula weight | 244537.2 |
