4TO0

Structure basis of cellular dNTP regulation, SAMHD1-GTP-dATP-dCTP complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	Deoxynucleoside triphosphate triphosphohydrolase SAMHD1	polymer	514	59604.2	4	UniProt (Q9Y3Z3) Pfam (PF01966) In PDB	Homo sapiens (Human)	dNTPase,Dendritic cell-derived IFNG-induced protein,DCIP,Monocyte protein 5,MOP-5,SAM domain and HD domain-containing protein 1
2	A, B, C, D	2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE	non-polymer		467.2	4	Chemie (DCP)
3	A, B, C, D	GUANOSINE-5'-TRIPHOSPHATE	non-polymer		523.2	4	Chemie (GTP)
4	A, B, C, D	2'-DEOXYADENOSINE 5'-TRIPHOSPHATE	non-polymer		491.2	4	Chemie (DTP)
5	A, C, D	MAGNESIUM ION	non-polymer		24.3	4	Chemie (MG)
6		water	water		18.0	139	Chemie (HOH)

Sequence modifications

A, B, C, D: 113 - 626 (UniProt: Q9Y3Z3)

PDB	External Database	Details
Arg 206	His 206	engineered mutation
Asn 207	Asp 207	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	238416.7
Non-Polymers*	Number of molecules	16
	Total formula weight	6023.3
All*	Total formula weight	244440.0

*Water molecules are not included.