4TLM
Crystal structure of GluN1/GluN2B NMDA receptor, structure 2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | receptor subunit GluN1 | polymer | 823 | 92722.3 | 2 | UniProt (C0KD18) Pfam (PF01094) Pfam (PF10613) Pfam (PF00060) UniProt (by SIFTS) (A0A1L8F5J9) | Xenopus laevis (African clawed frog) | N-methyl-D-aspartate receptor subunit NR1-8a |
| 2 | B, D (B, D) | receptor subunit GluN2B | polymer | 824 | 93088.5 | 2 | UniProt (A7XY94) Pfam (PF01094) Pfam (PF10613) Pfam (PF00060) | Xenopus laevis (African clawed frog) | Ionotropic glutamate receptor subunit NR2B |
| 3 | E, F, G, J, K... (A, B, C, D) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 7 | Chemie (NAG) | |||
| 4 | H (A) | 1-AMINOCYCLOPROPANECARBOXYLIC ACID | non-polymer | 101.1 | 1 | Chemie (1AC) | |||
| 5 | I, M (A, C) | 4-[(1R,2S)-3-(4-benzylpiperidin-1-yl)-1-hydroxy-2-methylpropyl]phenol | non-polymer | 339.5 | 2 | Chemie (QEM) | |||
| 6 | O (D) | trans-1-aminocyclobutane-1,3-dicarboxylic acid | non-polymer | 159.1 | 1 | Chemie (JEG) |
Sequence modifications
A, C: 22 - 828 (UniProt: C0KD18)
B, D: 20 - 381 (UniProt: A7XY94)
B, D: 382 - 825 (UniProt: A7XY94)
| PDB | External Database | Details |
|---|---|---|
| Ala 22 | Cys 22 | engineered mutation |
| Phe 51 | Lys 51 | engineered mutation |
| Phe 52 | Arg 52 | engineered mutation |
| Gln 300 | Asn 300 | engineered mutation |
| Gln 350 | Asn 350 | engineered mutation |
| Asp 368 | Asn 368 | engineered mutation |
| Asp 440 | Asn 440 | engineered mutation |
| Asp 469 | Asn 469 | engineered mutation |
| Ala 493 | Lys 493 | engineered mutation |
| Ala 494 | Lys 494 | engineered mutation |
| Ala 495 | Glu 495 | engineered mutation |
| Arg 602 | Gly 610 | engineered mutation |
| Leu 609 | Ile 617 | engineered mutation |
| Arg 648 | Asp 656 | engineered mutation |
| Glu 761 | Asn 769 | engineered mutation |
| Ser 829 | - | insertion |
| Arg 830 | - | insertion |
| Ala 831 | - | insertion |
| Glu 832 | - | insertion |
| Ala 833 | - | insertion |
| Lys 834 | - | insertion |
| Arg 835 | - | insertion |
| Met 836 | - | insertion |
| Lys 837 | - | insertion |
| Gly 838 | - | expression tag |
| Leu 839 | - | expression tag |
| Glu 840 | - | expression tag |
| Val 841 | - | expression tag |
| Leu 842 | - | expression tag |
| Phe 843 | - | expression tag |
| Gln 844 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ser 20 | Met 20 | engineered mutation |
| Arg 21 | Gly 21 | engineered mutation |
| Ala 22 | Cys 22 | engineered mutation |
| Glu 64 | Ala 64 | engineered mutation |
| Gln 69 | Asn 69 | engineered mutation |
| Cys 216 | Lys 216 | engineered mutation |
| Asp 343 | Asn 343 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Val 486 | Thr 490 | engineered mutation |
| Leu 601 | Val 615 | engineered mutation |
| Arg 640 | Glu 654 | engineered mutation |
| Arg 641 | Glu 655 | engineered mutation |
| Tyr 826 | - | insertion |
| Lys 827 | - | insertion |
| Ser 828 | - | insertion |
| Arg 829 | - | insertion |
| Ala 830 | - | insertion |
| Glu 831 | - | insertion |
| Ala 832 | - | insertion |
| Lys 833 | - | insertion |
| Arg 834 | - | insertion |
| Met 835 | - | insertion |
| Lys 836 | - | insertion |
| Gly 837 | - | expression tag |
| Leu 838 | - | expression tag |
| Glu 839 | - | expression tag |
| Val 840 | - | expression tag |
| Leu 841 | - | expression tag |
| Phe 842 | - | expression tag |
| Gln 843 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 371621.5 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 2487.6 | |
| All* | Total formula weight | 374109.2 |
