4TKG
Crystal Structure of human Tankyrase 2 in complex with AZD2281.
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | Tankyrase-2 | polymer | 227 | 25986.3 | 4 | UniProt (Q9H2K2) Pfam (PF00644) In PDB | Homo sapiens (Human) | TANK2,ADP-ribosyltransferase diphtheria toxin-like 6,ARTD6,Poly [ADP-ribose] polymerase 5B,TNKS-2,TRF1-interacting ankyrin-related ADP-ribose polymerase 2,Tankyrase II,Tankyrase-like protein,Tankyrase-related protein |
2 | A, B, C, D | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
3 | A, B, C, D | 4-(3-{[4-(cyclopropylcarbonyl)piperazin-1-yl]carbonyl}-4-fluorobenzyl)phthalazin-1(2H)-one | non-polymer | 434.5 | 4 | Chemie (09L) | |||
4 | A, B, C | GLYCEROL | non-polymer | 92.1 | 5 | Chemie (GOL) | |||
5 | water | water | 18.0 | 540 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 959 - 1164 (UniProt: Q9H2K2)
PDB | External Database | Details |
---|---|---|
Met 938 | - | initiating methionine |
Gly 939 | - | expression tag |
Ser 940 | - | expression tag |
Ser 941 | - | expression tag |
His 942 | - | expression tag |
His 943 | - | expression tag |
His 944 | - | expression tag |
His 945 | - | expression tag |
His 946 | - | expression tag |
His 947 | - | expression tag |
Ser 948 | - | expression tag |
Ser 949 | - | expression tag |
Gly 950 | - | expression tag |
Arg 951 | - | expression tag |
Glu 952 | - | expression tag |
Asn 953 | - | expression tag |
Leu 954 | - | expression tag |
Tyr 955 | - | expression tag |
Phe 956 | - | expression tag |
Gln 957 | - | expression tag |
Gly 958 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 103945.2 | |
Non-Polymers* | Number of molecules | 13 |
Total formula weight | 2460.0 | |
All* | Total formula weight | 106405.1 |