4SKN
A NUCLEOTIDE-FLIPPING MECHANISM FROM THE STRUCTURE OF HUMAN URACIL-DNA GLYCOSYLASE BOUND TO DNA
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | DNA (5'-D(*TP*GP*GP*GP*(D1P)P*GP*GP*CP*TP*T)-3') | polymer | 10 | 2998.9 | 1 | |||
| 2 | B (B) | DNA (5'-D(*AP*AP*AP*GP*CP*CP*GP*CP*CP*C)-3') | polymer | 10 | 2999.0 | 1 | |||
| 3 | C (E) | PROTEIN (URACIL-DNA GLYCOSYLASE) | polymer | 223 | 25587.2 | 1 | UniProt (P13051) Pfam (PF03167) | Homo sapiens (human) | UDG, UNG |
| 4 | D (E) | URACIL | non-polymer | 112.1 | 1 | Chemie (URA) | |||
| 5 | E, F, G (A, B, E) | water | water | 18.0 | 75 | Chemie (HOH) |
Sequence modifications
E: 85 - 304 (UniProt: P13051)
| PDB | External Database | Details |
|---|---|---|
| Met 82 | - | cloning artifact |
| Glu 83 | - | cloning artifact |
| Phe 84 | - | cloning artifact |
| Asn 145 | Asp 145 | engineered mutation |
| Arg 272 | Leu 272 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 31585.1 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 112.1 | |
| All* | Total formula weight | 31697.2 |
