4RXS
The structure of GTP-dTTP-bound SAMHD1
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | polymer | 539 | 62486.2 | 2 | UniProt (Q9Y3Z3) Pfam (PF01966) In PDB | Homo sapiens (human) | dNTPase, Dendritic cell-derived IFNG-induced protein, DCIP, Monocyte protein 5, MOP-5, SAM domain and HD domain-containing protein 1 |
2 | A | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 2 | Chemie (GTP) | |||
3 | A, B | THYMIDINE-5'-TRIPHOSPHATE | non-polymer | 482.2 | 4 | Chemie (TTP) | |||
4 | A, B | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
5 | water | water | 18.0 | 407 | Chemie (HOH) |
Sequence modifications
A, B: 109 - 626 (UniProt: Q9Y3Z3)
PDB | External Database | Details |
---|---|---|
Met 88 | - | expression tag |
Gly 89 | - | expression tag |
Ser 90 | - | expression tag |
Ser 91 | - | expression tag |
His 92 | - | expression tag |
His 93 | - | expression tag |
His 94 | - | expression tag |
His 95 | - | expression tag |
His 96 | - | expression tag |
His 97 | - | expression tag |
Ser 98 | - | expression tag |
Ser 99 | - | expression tag |
Gly 100 | - | expression tag |
Glu 101 | - | expression tag |
Asn 102 | - | expression tag |
Leu 103 | - | expression tag |
Tyr 104 | - | expression tag |
Phe 105 | - | expression tag |
Gln 106 | - | expression tag |
Gly 107 | - | expression tag |
Ser 108 | - | expression tag |
Tyr 266 | Cys 266 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 124972.4 | |
Non-Polymers* | Number of molecules | 8 |
Total formula weight | 3023.6 | |
All* | Total formula weight | 127996.0 |