4RXQ
The structure of GTP-dUTP-bound SAMHD1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | polymer | 539 | 62486.2 | 2 | UniProt (Q9Y3Z3) Pfam (PF01966) | Homo sapiens (human) | dNTPase, Dendritic cell-derived IFNG-induced protein, DCIP, Monocyte protein 5, MOP-5, SAM domain and HD domain-containing protein 1 |
| 2 | C, F (A) | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 2 | Chemie (GTP) | |||
| 3 | D, E, I, J (A, B) | DEOXYURIDINE-5'-TRIPHOSPHATE | non-polymer | 468.1 | 4 | Chemie (DUT) | |||
| 4 | G, H (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 5 | K, L (A, B) | water | water | 18.0 | 518 | Chemie (HOH) |
Sequence modifications
A, B: 109 - 626 (UniProt: Q9Y3Z3)
| PDB | External Database | Details |
|---|---|---|
| Met 88 | - | expression tag |
| Gly 89 | - | expression tag |
| Ser 90 | - | expression tag |
| Ser 91 | - | expression tag |
| His 92 | - | expression tag |
| His 93 | - | expression tag |
| His 94 | - | expression tag |
| His 95 | - | expression tag |
| His 96 | - | expression tag |
| His 97 | - | expression tag |
| Ser 98 | - | expression tag |
| Ser 99 | - | expression tag |
| Gly 100 | - | expression tag |
| Glu 101 | - | expression tag |
| Asn 102 | - | expression tag |
| Leu 103 | - | expression tag |
| Tyr 104 | - | expression tag |
| Phe 105 | - | expression tag |
| Gln 106 | - | expression tag |
| Gly 107 | - | expression tag |
| Ser 108 | - | expression tag |
| Tyr 266 | Cys 266 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 124972.4 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 2967.5 | |
| All* | Total formula weight | 127939.9 |
