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4RX4

Crystal structure of VH1-46 germline-derived CD4-binding site-directed antibody 8ANC134 in complex with HIV-1 clade A Q842.d12 gp120

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, D
(G, E)
HIV-1 Clade A Q842.d12 gp120polymer35439667.82Pfam (PF00516)
UniProt (by SIFTS) (Q8JDI3)
Human immunodeficiency virus 1 (11676)
2B, E
(H, A)
8ANC134 Heavy chainpolymer22924449.72Homo sapiens (human)
3C, F
(L, D)
8ANC134 Light Chainpolymer21323425.02Homo sapiens (human)
4AA, G, H, I, J...
(E, G)
2-acetamido-2-deoxy-beta-D-glucopyranosenon-polymer221.211Chemie (NAG)
5BA, DA, EA, FA, GA...
(E, A, D, G, L)
SULFATE IONnon-polymer96.112Chemie (SO4)
6CA, N, O, P, S
(E, G)
1,2-ETHANEDIOLnon-polymer62.15Chemie (EDO)
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains6
Total formula weight175085.1
Non-Polymers*Number of molecules28
Total formula weight3896.4
All*Total formula weight178981.5
*Water molecules are not included.

246031

PDB entries from 2025-12-10

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