4RVX
Crystal structure of multidrug-resistant clinical isolate A02 HIV-1 protease in complex with non-peptidic inhibitor, GRL079
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D | HIV-1 Protease | polymer | 99 | 10863.7 | 4 | UniProt (Q9J006) Pfam (PF00077) In PDB | Human immunodeficiency virus 1 | |
| 2 | A, D | (4S)-4-amino-N-[(2S,3S)-3-hydroxy-4-{[(4-methoxyphenyl)sulfonyl](2-methylpropyl)amino}-1-phenylbutan-2-yl]-3,4-dihydro-2H-chromene-6-carboxamide | non-polymer | 581.7 | 2 | Chemie (79G) | |||
| 3 | water | water | 18.0 | 230 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 99 (UniProt: Q9J006)
| PDB | External Database | Details |
|---|---|---|
| Cys 95 | Phe 95 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 43455.0 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1163.4 | |
| All* | Total formula weight | 44618.4 |
