4RVJ
Crystal structure of multidrug-resistant clinical isolate A02 HIV-1 protease in complex with amprenavir
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | HIV-1 protease | polymer | 99 | 10863.7 | 4 | UniProt (Q9J006) | Human immunodeficiency virus 1 | |
| 2 | E, F (B, D) | {3-[(4-AMINO-BENZENESULFONYL)-ISOBUTYL-AMINO]-1-BENZYL-2-HYDROXY-PROPYL}-CARBAMIC ACID TETRAHYDRO-FURAN-3-YL ESTER | non-polymer | 505.6 | 2 | Chemie (478) PubChem (2177) PubChem (22868212) PubChem (65016) PubChem (44342222) PubChem (59964701) PubChem (68088939) PubChem (68336859) PubChem (68164690) PubChem (441385) PubChem (92209736) PubChem (124638074) PubChem (10885665) PubChem (11168069) PubChem (6540587) PubChem (9898472) PubChem (141823677) | |||
| 3 | G, H, I, J (A, B, C, D) | water | water | 18.0 | 483 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 99 (UniProt: Q9J006)
| PDB | External Database | Details |
|---|---|---|
| Cys 95 | Phe 95 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 43455.0 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1011.3 | |
| All* | Total formula weight | 44466.2 |
