4RVJ
Crystal structure of multidrug-resistant clinical isolate A02 HIV-1 protease in complex with amprenavir
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D | HIV-1 protease | polymer | 99 | 10863.7 | 4 | UniProt (Q9J006) Pfam (PF00077) In PDB | Human immunodeficiency virus 1 | |
| 2 | B, D | {3-[(4-AMINO-BENZENESULFONYL)-ISOBUTYL-AMINO]-1-BENZYL-2-HYDROXY-PROPYL}-CARBAMIC ACID TETRAHYDRO-FURAN-3-YL ESTER | non-polymer | 505.6 | 2 | Chemie (478) | |||
| 3 | water | water | 18.0 | 483 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 99 (UniProt: Q9J006)
| PDB | External Database | Details |
|---|---|---|
| Cys 95 | Phe 95 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 43455.0 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1011.3 | |
| All* | Total formula weight | 44466.2 |
