4RTV

Crystal structure of the Src tyrosine kinase SH3 domain S94A/Q128R mutant in complex with the high affinity synthetic peptide APP12

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Proto-oncogene tyrosine-protein kinase Src	polymer	61	6918.6	1	UniProt (P00523) Pfam (PF00018) In PDB	Gallus gallus (bantam chickens)	Proto-oncogene c-Src, pp60c-src, p60-Src
2	B	APP12 peptide	polymer	13	1412.7	1
3		water	water		18.0	33	Chemie (HOH)

Sequence modifications

A: 85 - 141 (UniProt: P00523)

PDB	External Database	Details
Gly 81	-	expression tag
Ser 82	-	expression tag
His 83	-	expression tag
Met 84	-	expression tag
Ala 94	Ser 94	engineered mutation
Arg 128	Gln 128	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	8331.3
All*	Total formula weight	8331.3

*Water molecules are not included.