4RQS
Crystal structure of fully glycosylated HIV-1 gp120 core bound to CD4 and 17b Fab
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | B | 2-domain CD4 | polymer | 185 | 20503.3 | 1 | UniProt (P01730) Pfam (PF00047) Pfam (PF05790) In PDB | Homo sapiens (Human) | |
2 | C | 17b Fab Light Chain | polymer | 214 | 23399.9 | 1 | Homo sapiens (Human) | ||
3 | D | 17b Fab Heavy Chain | polymer | 229 | 24457.4 | 1 | Homo sapiens (Human) | ||
4 | G | HIV-1 YU2 gp120 core chimeric protein | polymer | 313 | 34838.7 | 1 | UniProt (P35961) Pfam (PF00516) In PDB | Human immunodeficiency virus type 1 (isolate YU2) (HIV-1) | |
5 | A | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1559.4 | 1 | In PDB GlyTouCan (G68668TB) | |||
6 | E, H, I, J | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 4 | In PDB GlyTouCan (G42666HT) | |||
7 | F, K, L | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 3 | In PDB GlyTouCan (G15407YE) | |||
8 | G | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) |
Sequence modifications
B: 1 - 183 (UniProt: P01730)
G: 83 - 127 (UniProt: P35961)
G: 195 - 297 (UniProt: P35961)
G: 330 - 492 (UniProt: P35961)
PDB | External Database | Details |
---|---|---|
Asn 184 | - | expression tag |
Thr 185 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Gly 79 | - | expression tag |
Ala 80 | - | expression tag |
Arg 81 | - | expression tag |
Ser 82 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Gly 128 | - | linker |
Ala 129 | - | linker |
Gly 194 | - | linker |
PDB | External Database | Details |
---|---|---|
Gly 298 | - | linker |
Ala 299 | - | linker |
Gly 300 | - | linker |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 103199.2 | |
Branched | Number of molecules | 8 |
Total formula weight | 5016.6 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 221.2 | |
All* | Total formula weight | 108437.1 |