4RQS
Crystal structure of fully glycosylated HIV-1 gp120 core bound to CD4 and 17b Fab
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (B) | 2-domain CD4 | polymer | 185 | 20503.3 | 1 | UniProt (P01730) Pfam (PF00047) Pfam (PF05790) | Homo sapiens (Human) | |
| 2 | B (C) | 17b Fab Light Chain | polymer | 214 | 23399.9 | 1 | Homo sapiens (Human) | ||
| 3 | C (D) | 17b Fab Heavy Chain | polymer | 229 | 24457.4 | 1 | Homo sapiens (Human) | ||
| 4 | D (G) | HIV-1 YU2 gp120 core chimeric protein | polymer | 313 | 34838.7 | 1 | UniProt (P35961) Pfam (PF00516) | Human immunodeficiency virus type 1 (isolate YU2) (HIV-1) | |
| 5 | E (A) | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1559.4 | 1 | In PDB GlyTouCan (G68668TB) | |||
| 6 | F, H, I, J (E, H, I, J) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 4 | In PDB GlyTouCan (G42666HT) | |||
| 7 | G, K, L (F, K, L) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 3 | In PDB GlyTouCan (G15407YE) | |||
| 8 | M (G) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) |
Sequence modifications
B: 1 - 183 (UniProt: P01730)
G: 83 - 127 (UniProt: P35961)
G: 195 - 297 (UniProt: P35961)
G: 330 - 492 (UniProt: P35961)
| PDB | External Database | Details |
|---|---|---|
| Asn 184 | - | expression tag |
| Thr 185 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 79 | - | expression tag |
| Ala 80 | - | expression tag |
| Arg 81 | - | expression tag |
| Ser 82 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 128 | - | linker |
| Ala 129 | - | linker |
| Gly 194 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Gly 298 | - | linker |
| Ala 299 | - | linker |
| Gly 300 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 103199.2 | |
| Branched | Number of molecules | 8 |
| Total formula weight | 5016.6 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 221.2 | |
| All* | Total formula weight | 108437.1 |
