4RQE

human Seryl-tRNA synthetase dimer complexed with two molecules of tRNAsec

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, C)	Serine--tRNA ligase, cytoplasmic	polymer	522	59836.3	2	UniProt (P49591) Pfam (PF02403) Pfam (PF00587)	Homo sapiens (human)	Seryl-tRNA synthetase, SerRS, Seryl-tRNA(Ser/Sec) synthetase
2	C, D (B, D)	selenocysteine tRNA	polymer	90	28948.1	2		Homo sapiens
3	E, G (A, C)	SERINE	non-polymer		105.1	2	Chemie (SER)
4	F, H (A, C)	PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER	non-polymer		506.2	2	Chemie (ANP)

Sequence modifications

A, C: 1 - 514 (UniProt: P49591)

PDB	External Database	Details
Thr 156	Glu 156	engineered mutation
Ser 157	Arg 157	engineered mutation
Leu 515	-	expression tag
Glu 516	-	expression tag
His 517	-	expression tag
His 518	-	expression tag
His 519	-	expression tag
His 520	-	expression tag
His 521	-	expression tag
His 522	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	177568.7
Non-Polymers*	Number of molecules	4
	Total formula weight	1222.6
All*	Total formula weight	178791.3

*Water molecules are not included.