4RN6
Structure of prethrombin-2 mutant s195a bound to the active site inhibitor argatroban
Replaces: 4HFYEntity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Thrombin heavy chain | polymer | 290 | 33393.3 | 2 | UniProt (P00734) Pfam (PF09396) Pfam (PF00089) | Homo sapiens (human) | |
| 2 | C, D (A, B) | (2R,4R)-4-methyl-1-(N~2~-{[(3S)-3-methyl-1,2,3,4-tetrahydroquinolin-8-yl]sulfonyl}-L-arginyl)piperidine-2-carboxylic acid | non-polymer | 508.6 | 2 | BIRD (PRD_000889) Chemie (15U) |
Sequence modifications
A, B: 1 - 247 (UniProt: P00734)
| PDB | External Database | Details |
|---|---|---|
| Ala 195 | Ser 568 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 66786.5 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1017.3 | |
| All* | Total formula weight | 67803.8 |
